Episodes

The longevity advantage of genetic deficiencies in growth hormone/IGF-1 signaling | Valter Longo

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo discusses the longevity-conferring effects of diminishing the pro-aging IGF-1 pathway.

Cancer manipulates biologically useful systems to its selfish advantage (dual role of autophagy)

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo discusses how autophagy may function in both normal and cancer cells.

IGF-1 plays a key role in the regenerative processes activated by prolonged fasting | Valter Longo

Posted on July 15th 2019 (over 2 years)

Dr. Rhonda Patrick and Dr. Valter Longo discuss how IGF-1 is involved in the regenerative aspect of the two phases of fasting and refeeding.

Origin of the Fasting Mimicking Diet & the path to broader clinical acceptance | Valter Longo

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo discusses the origin of the fasting-mimicking diet and a possible shift from a drug-centered mentality to one which allows the body to heal itself.

Fasting plus chemotherapy shown to be more effective than chemo alone in mouse research models

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo describes how fasting may reduce the toxicity of chemotherapeutic drugs while also maximizing their impact in the treatment of cancer.

Reversing immunosenescence — lymphocytes return to youthful levels after fasting (adaptive immunity)

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo describes how fasting promotes the immune system to return to a more youthful profile.

Fasting mimicking diet treatment for multiple sclerosis (remyelinating axons & halting autoimmunity)

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo describes how the fasting-mimicking diet can be beneficial in the treatment of various diseases, including multiple sclerosis.

Mitochondrial use of fatty acids as mechanism for cancer cell death during fasting | Valter Longo

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo explains how fatty acid usage by cancer cells weakens them and makes them more susceptible to immune system clearance.

Prolonged fasting and fasting-mimicking preferentially deplete visceral fat rather than lean mass

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo describes how a fasting-mimicking diet can be used for fat loss while preserving lean muscle mass.

Caloric restriction vs. periodic fasting and the importance of re-feeding after a fast

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo explains the difference between caloric restriction and periodic fasting and highlights the importance of refeeding after a fast.

The role of fasting-induced ketosis in stem cell activation and cell renewal | Valter Longo

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo discusses how fasting can play a role in the activation and renewal of stem cells by altering the metabolic profile.

Inflammation as a biomarker of successful aging — evidence in semi-supercentenarians

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo describes how a fasting-mimicking diet can reduce markers of inflammation, resetting our biological systems to a more youthful state.

Prolonged fasting as a powerful way to regenerate and rebuild systems | Valter Longo

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo describes how prolonged fasting and subsequent refeeding, sends signals to the body to systematically shrink and rebuild organ systems.

The unique effects of multi-day prolonged fasts (requires more than 48 hours) - Valter Longo

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo explains the benefits of a prolonged fast.

Dr. Valter Longo's personal approach to fasting and weight management

Posted on July 15th 2019 (over 2 years)

Dr. Valter Longo describes his approach to fasting and his philosophy that if an eating protocol is too regimented people will abandon it.

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