Episodes

Inflammation as a biomarker of successful aging — evidence in semi-supercentenarians

Posted on July 15th 2019 (almost 5 years)

Dr. Valter Longo describes how a fasting-mimicking diet can reduce markers of inflammation, resetting our biological systems to a more youthful state.

Prolonged fasting as a powerful way to regenerate and rebuild systems | Valter Longo

Posted on July 15th 2019 (almost 5 years)

Dr. Valter Longo describes how prolonged fasting and subsequent refeeding, sends signals to the body to systematically shrink and rebuild organ systems.

The unique effects of multi-day prolonged fasts (requires more than 48 hours) - Valter Longo

Posted on July 15th 2019 (almost 5 years)

Dr. Valter Longo explains the benefits of a prolonged fast.

Dr. Valter Longo's personal approach to fasting and weight management

Posted on July 15th 2019 (almost 5 years)

Dr. Valter Longo describes his approach to fasting and his philosophy that if an eating protocol is too regimented people will abandon it.

Mitophagy: a signal for mitochondrial biogenesis, metabolic adaptation, and cellular differentiation

Posted on July 15th 2019 (almost 5 years)

Dr. Guido Kroemer describes mitophagy, a cellular signal for mitochondrial biogenesis, and a key player in other physiological processes.

How the cell prioritizes and targets organelles and protein aggregates for degradation by autophagy

Posted on July 15th 2019 (almost 5 years)

Dr. Guido Kroemer describes the cellular process of autophagy and what factors trigger its activation.

Increasing general autophagy as a treatment for neurodegenerative diseases like Parkinson's disease

Posted on July 15th 2019 (almost 5 years)

Dr. Guido Kroemer describes how mitophagy contributes to the pathophysiology of neurodegenerative disease and how autophagy might mitigate these processes.

Fasting associated with sickness behavior critical to surviving bacterial infection | Guido Kroemer

Posted on July 15th 2019 (almost 5 years)

Dr. Guido Kroemer describes how fasting associated with sickness behavior is critical to surviving infection.

Autophagy and cancer: a crucial role in immunosurveillance and chemotherapeutic treatment

Posted on July 15th 2019 (almost 5 years)

Dr. Guido Kroemer describes the complex relationship that exists between cancer cells, the immune system, and autophagy.

Deprivation of nutrients (starvation) and other signals that play a key role in inducing autophagy

Posted on July 15th 2019 (almost 5 years)

Dr. Guido Kroemer discusses changes that occur within cells that signal the need to induce autophagy.

Exercise-induced autophagy and its role in preventing diabetes | Guido Kroemer

Posted on July 15th 2019 (almost 5 years)

Dr. Guido Kroemer describes the anti-diabetes and anti-obesity effects of exercise-induced autophagy.

Can limiting protein intake (or other selective nutrient depletion) induce autophagy?

Posted on July 15th 2019 (almost 5 years)

Dr. Guido Kroemer describes the interplay between protein deacetylation and autophagy.

Periodic fasting has the same longevity benefit as caloric restriction | Guido Kroemer

Posted on July 15th 2019 (almost 5 years)

Dr. Guido Kroemer describes how intermittent fasting recapitulates the life-extension benefits of caloric restriction without some of the drawbacks.

Does coffee induce autophagy? | Guido Kroemer

Posted on July 15th 2019 (almost 5 years)

Dr. Guido Kroemer discusses the autophagy-inducing qualities of coffee.

Autophagy expert: Dr. Guido Kroemer's personal take on fasting, eating and other lifestyle habits

Posted on July 15th 2019 (almost 5 years)

Dr. Guido Kroemer describes the autophagy-inducing behaviors he practices as part of his healthy lifestyle.

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