Episodes

How lifestyle factors can slow or accelerate epigenetic aging | Steve Horvath

Posted on December 30th 2020 (7 months)

Conventional health advice, such as healthy eating, physical activity, and education level are linked with slowed epigenetic aging, albeit weakly, and obesity, sleep deprivation, and smoking are linked with accelerated epigenetic aging.

Can senolytic drugs improve epigenetic aging? | Steve Horvath

Posted on December 30th 2020 (7 months)

In this clip, Dr. Steve Horvath discusses how epigenetic aging differs from senescence-mediated aging.

GrimAge vs. Telomere length: a better biomarker for aging | Steve Horvath

Posted on December 29th 2020 (7 months)

The DNAm GrimAge epigenetic clock may be a more reliable predictor of healthspan and lifespan than traditional hallmarks of aging like telomeres.

How epigenetic predictions align with onset of cancer, Parkinson's and Alzheimer's | Steve Horvath

Posted on December 29th 2020 (7 months)

A person's epigenetic age correlates with their risk for developing major diseases of aging like cancer, Alzheimer's disease, and Parkinson's.

Melted Test Tubes! DNA methylation, a "forensically stable" measure of aging | Steve Horvath

Posted on December 28th 2020 (7 months)

The stability of methylation patterns on DNA samples means the data can be trusted more in the lab when investigating anti-aging interventions.

GrimAge, an epigenetic time-to-death prediction for anti-aging trials | Steve Horvath

Posted on December 28th 2020 (7 months)

The GrimAge clock (named for the Grim Reaper) predicts lifespan and healthspan in units of years and tests whether potential lifestyle interventions may slow or reverse biological aging.

Horvath epigenetic aging clocks measure two types of age: biological aging vs. chronological aging

Posted on December 28th 2020 (7 months)

In this clip, Dr. Steve Horvath explains the differences between chronological age and biological age.

Epigenetic age vs. clinical biomarkers as tools for understanding aging | Steve Horvath

Posted on December 28th 2020 (7 months)

Sometimes a person's clinical biomarkers doesn't accurately reflect how well they are aging, but epigenetic clocks may give a more reliable insight into their aging.

Heredity plays a key role in epigenetic aging speed | Steve Horvath

Posted on December 28th 2020 (7 months)

Evidence indicates that the heritability of epigenetic aging is about 40 percent. This is seen in supercentenarians and their offspring, who tend to age slower than their younger counterparts.

Vitamin D and omega-3 may slow epigenetic aging | Steve Horvath

Posted on December 27th 2020 (7 months)

Emerging evidence now suggests that supplemental omega-3 fatty acids or vitamin D slow epigenetic aging.

How does one identify a good source of broccoli seeds? | Jed Fahey

Posted on December 4th 2020 (8 months)

In this clip, sulforaphane expert Dr. Jed Fahey describes some of the problems associated with choosing a good source of seeds for sprouting.

Is sulforaphane present in all cruciferous vegetables? | Jed Fahey

Posted on December 4th 2020 (8 months)

In this clip, Dr. Jed Fahey enumerates the vegetables in which sulforaphane is found.

How long do the health effects of broccoli sprouts last? | Jed Fahey

Posted on December 4th 2020 (8 months)

In this clip, Dr. Jed Fahey describes how long the health effects of broccoli sprouts last.

Sulforaphane increases glutathione in the brain | Jed Fahey

Posted on December 4th 2020 (8 months)

In this clip, Dr. Jed Fahey discusses how sulforaphane promotes glutathione production in the brain, even with long-term consumption.

Sulforaphane promotes detoxification of heavy metals | Jed Fahey

Posted on December 4th 2020 (8 months)

In this clip, Dr. Jed Fahey describes how sulforaphane facilitates the detoxication of heavy metals by increasing glutathione synthesis.

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