1. 5
Note: All comments on this story will also be visible on its associated episode page.
  1. You must first login , or register before you can comment.

    Markdown formatting available

  2. 1

    Can I have more information on this Kappa Antagonist depression drug?

    1. 1

      Rhonda - I’ve been a listener since you started and I can definitively say your discussion with Dr. Charles Raison was the best of all. I enjoyed how the talk ranged from genetic and molecular mechanisms of depression to ancient shamanic rituals and how they might have modern applications. Keep up the great work!

      1. 1

        Dear Dr. Patrick,

        Thank you very much for all you wonderful videos and podcasts. I can hardly wait for new ones to come out. (and then listen to them 5 times before I start to understand) A lightbulb went up while I was listening to your talk with Dr. Charles Raison. Many years I would get periodical bouts of depression until I realised that the coincided with outbreaks of herpes. Two days before I would get a herpes sore I would feel really down and hopeless. (it would be triggered by certain kind of alcohols, I like to drink a lot) Maybe that is something for Dr. Raison to look into for his theory about the connection between inflammation and depression. Aside of that and the occasional panic about not being able to pay my bills I have no problems with depression. Thank you again and please keep them coming. And as soon as I get financially stable I happily contribute to your efforts.

        1. 1

          This was a phenomenally interesting interview, that I hope paves the way for better treatments for depression. It leads me to wonder about the reasons behind heat dis-regulation during menopause (aka hot flashes and night sweats) and if hyperthermia might be a useful treatment.

          1. 1

            Very interesting podcast, as usual. Thank you! I’m curious about how long the hyperthermia sessions were in the experiments. How long does it generally take in a sauna or hot bath to reach 38.5 C and how long should one stay at that temp? Is it reasonable to use an oral thermometer to check yourself?

            1. 1

              Ted, I was asking myself the same thing about the oral thermometer. Who knows if it would be reliable enough! Great question though.

              Having read the more recent paper on WBH from Dr. Raison’s group, it looks like the time it took each person to reach 38.5 C varied from person to person.

              Here’s the relevant section…

              Time to attainment of this core body temperature varied from patient to patient but required a mean (SD) length of 107 (19.4) minutes (range, 81-140 minutes). When core body temperature reached 38.5°C, the infrared lights and heating coils were turned off, and participants remained recumbent in the Heckel device and entered a 60-minute cool-down phase.