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Antinociception, but not sedative or gastric injury response, was observed in a significant and dose-dependent manner with the BSE (50–500 mg kg−1, i.p. and 500–2000 mg kg−1, p.o.) in comparison to the control group; these effects resembled those observed with the analgesic tramadol (30 mg kg−1, i.p.) in writhing and formalin assessments.

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