A high dose of fish oil (4g/day) lowered triglyceride levels by 20-30% in people with high triglycerides according to an analysis of 17 randomized controlled trials reviewed by the scientific advisory council at the American Heart Association.

“In analyzing the current scientific data, the advisory panel found:

•For most people with high triglycerides (200 to 499 mg/dL), prescription doses of omega-3 fatty acids using drugs with either EPA+DHA or EPA alone can reduce triglyceride by 20 to 30%.

•Contrary to common perception, the formula that contains both EPA and DHA does not increase the “bad” form of cholesterol (LDL-C) among most people with high triglyceride levels (200-499 mg/dL). However, when the drug is given to people with very high triglyceride levels at 500 mg/dL or greater, LDL-C may increase.

•The panel’s review found that prescription omega-3 fish oil is effective in reducing triglyceride levels regardless of whether people are on statin therapy.

•In a recent large, randomized placebo-controlled study called REDUCE-IT, researchers found that the EPA-only medication combined with statin medication resulted in a 25% reduction in major cardiovascular events (heart attack, stroke and cardiovascular death) among people with high triglycerides."