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From the article:
BDNF infused directly into the infralimbic prefrontal cortex in rats was found to extinguish conditioned fear, and BDNF levels were found to modulate the amount of fear extinction.
Reduced ability to adapt and therapeutically respond to exposure therapy for post-traumatic stress disorder in humans:
They found that patients with the Met-66 allele of BDNF [less functional variant of the gene coding for BDNF], compared with patients with the Val/Val allele, showed poorer response to exposure therapy.
“This paper reflects an important and significant advance, in translating recent ground-breaking findings in animal and human neuroscience into clinically anxious populations,” said first author Dr. Kim Felmingham.