Anti-epileptic drugs have been found to cause endocrine abnormalities and to interfere with metabolic pathways. That said, it is interesting to see the link with a keto diet here. Besides glutamate and K/NA voltage gated ion channel involvement, calcium influx is also involved in epileptogenesis. So, it will be interesting to tease out the culprits and then find the solution.
Having looked into it further there is a comment “Older antiepileptic
drugs (AEDs) can adversely affect bone health by directly
affecting the cells of bone formation and absorption or by secondary
effects on calcium and vitamin D metabolism”. The study later reports that some of the participants had tried and failed 8 AEDs which could suggest that they are responsible for the continued adverse effects on bone health, rather than it being a direct result of the Ketogenic diet.
For speculative purposes, as the participants already had a “poor” rating does this show correlation rather than causation? Could the have a genetic predisposition to bone mineral loss etc rather than it being a direct result of the ketogenic diet? Or is there an underlying mechanism of ketosis that would directly influence the composition of bone minerals.
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Anti-epileptic drugs have been found to cause endocrine abnormalities and to interfere with metabolic pathways. That said, it is interesting to see the link with a keto diet here. Besides glutamate and K/NA voltage gated ion channel involvement, calcium influx is also involved in epileptogenesis. So, it will be interesting to tease out the culprits and then find the solution.
Having looked into it further there is a comment “Older antiepileptic drugs (AEDs) can adversely affect bone health by directly affecting the cells of bone formation and absorption or by secondary effects on calcium and vitamin D metabolism”. The study later reports that some of the participants had tried and failed 8 AEDs which could suggest that they are responsible for the continued adverse effects on bone health, rather than it being a direct result of the Ketogenic diet.
For speculative purposes, as the participants already had a “poor” rating does this show correlation rather than causation? Could the have a genetic predisposition to bone mineral loss etc rather than it being a direct result of the ketogenic diet? Or is there an underlying mechanism of ketosis that would directly influence the composition of bone minerals.