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Transplanting senescent cells into young mice caused physical dysfunction and decreased lifespan when transplanted into old mice. On the other hand, selective clearance of senescent cells increased lifespan by 36% and improved physical function in old age.
Drugs that selectively target senescent cells are referred to as senolytics. This study also showed that senolytics killed human senescent cells in human fat samples.
To learn more about what causes cellular senescence, how it accelerates aging and plays a role in age-related diseases, and possible ways to prevent it…check out my podcast with Dr. Judi Campisi: