Amyloid-beta produced in peripheral tissues provides a link between diabetes and Alzheimer’s disease risk. Type 2 diabetes, a metabolic disorder characterized by glucose intolerance and insulin resistance, poses a significant public health concern, affecting roughly 470 million people worldwide. Having type 2 diabetes greatly increases a person’s risk of developing Alzheimer’s disease, but scientists don’t fully understand the mechanisms that drive the increased risk. Findings from a recent study suggest that amyloid-beta produced in tissues outside the brain provides the link between type 2 d... brain alzheimer's diabetes neurodegeneration
Read moreDr. Mark Mattson discusses how stress is essential to human survival and how exercise and intermittent fasting induce stress to promote health. ... fasting exercise alzheimer's inflammation stress time-restricted eating
Watch nowHyperglycemia, which occurs when glucose levels in the blood rise to dangerous levels, is a hallmark of diseases such as metabolic syndrome and type 2 diabetes. The effects of hyperglycemia are well documented and include cellular damage, inflammation, and pro-cancer effects (https://pubmed.ncbi.nlm.nih.gov/27931833/); however, few studies have elucidated the cellular mechanisms of hyperglycemia. Findings of a new report suggest mitochondrial damage explains the connection between hyperglycemia and disease. Glucose is consumed in the diet from simple sugars and starches. Glucose transport pro... sugar ketogenic diet
Read moreSulforaphane is a plant-based dietary compound derived from cruciferous vegetables such as broccoli (especially broccoli sprouts), kale, and others. It exerts a wide range of beneficial health effects on the human body. A new study suggests that sulforaphane mitigates sarcopenia and cardiac dysfunction via activation of Nrf2. Sarcopenia, the loss of muscle tissue that occurs during the aging process, and cardiac dysfunction are common features of aging. Key players in the pathophysiology of these conditions are mitochondrial dysfunction and oxidative damage. Nrf2 is a cellular protein that ... sulforaphane nrf2
Read moreA common feature in many chronic inflammatory diseases is dysbiosis – alterations in the type and number of microbes that typically reside in the human gut. Some of these microbes are highly motile due to the presence of flagella, which contributes to the microbes' pathogenic qualities. A new study suggests that immunization against the protein flagellin may confer protection against some chronic inflammatory diseases. Flagellins are structural components of the flagella of gram-negative bacteria. Flagella provide bacteria motility, which facilitates penetration of the gut mucosa and drives t... inflammation protein
Read moreKale supplementation increased heat shock proteins, lowered oxidative damage, and suppressed cognitive decline by improving spatial and learning memory in mice with a premature aging phenotype. I've talked quite a bit about heat shock proteins which are robustly activated by heat stress (ie. sauna, exercise, hot bath etc.). They are molecular chaperones that play a critical role in preventing protein aggregation, damaged proteins, and the suppression of neuronal cell death. They have also shown to be protective against neurodegenerative diseases. The compound found in kale responsible for incr... brain micronutrients heat stress neurons protein
Read moreDr. Rhonda Patrick makes her fifth appearance on the Joe Rogan Experience. ... nutrition vitamin d metabolism diabetes telomeres omega-3 inflammation depression dna damage stem cells micronutrients mitochondria autophagy autism schizophrenia resveratrol sulforaphane insulin blue light
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