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      <h3 class="bold">
        [Podcast] The Best Type of Exercise for Longevity
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      Dr. Rhonda Patrick and exercise physiologist Brady Holmer discuss a new study which challenges the current exercise guidelines.
...
          <span class="search-tag">exercise</span>
          <span class="search-tag">mitochondria</span>
          <span class="search-tag">muscle</span>
          <span class="search-tag">aerobic</span>
          <span class="search-tag">cardiovascular</span>
          <span class="search-tag">bdnf</span>
          <span class="search-tag">metabolism</span>
          <span class="search-tag">exercise snacks</span>
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        [Story] Regular blood donation promotes beneficial stem cell mutations while minimizing disease risk by inducing genetic changes that preferentially support healthy red blood cell production.
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</a>    <p>
      Donating blood is an act of generosity that saves lives, yet few donors think about how it affects their own health. Each donation triggers a surge in blood cell production, a process that could subtly shape the long-term health of blood-forming stem cells. A recent study found that frequent blood donation promotes the expansion of specific blood stem cell mutations that support healthy red blood cell production.
Researchers analyzed blood samples from 217 older men who had donated more than 100 times and compared them to 212 men who had donated fewer than 10 times. They looked for clonal hema...
          <span class="search-tag">genetics</span>
          <span class="search-tag">immune system</span>
          <span class="search-tag">cancer</span>
          <span class="search-tag">stem cells</span>
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        [Story] Quitting smoking can extend life expectancy by up to eight years, even when cessation occurs later in life.
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      Lighting up a cigarette shaves years off a person&#39;s life, shortening their lifespan by as much as a decade. However, a recent study found that quitting smoking, even later in life, can extend a person&#39;s life expectancy by as much as eight years—depending on how early they quit.
Researchers analyzed data from several large cohort studies and national death records to estimate the effects of smoking on life expectancy for people who never smoked, those who currently smoke, and those who previously smoked. They focused on people who quit at ages ranging from 35 to 75, assessing the years of life ...
          <span class="search-tag">tobacco</span>
          <span class="search-tag">mortality</span>
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        [Topic] Multivitamins
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</a>    <p>
      [toc position=&#39;left&#39;]
Introduction
Micronutrient deficiencies are widespread. Up to 70% of Americans don’t get enough vitamin D, nearly 50% fall short of their magnesium needs, and 35% have an insufficient intake of calcium.
These deficiencies and insufficiencies ravage our health. Inadequate vitamin D increases mortality risk. A magnesium deficiency can accelerate biological aging. Folate deficiency by itself can produce a level of DNA damage that is equivalent to or in excess of an acute exposure to radiation  (https://www.cambridge.org/core/journals/nutrition-research-reviews/article/nutrit...
          <span class="search-tag">vitamin a</span>
          <span class="search-tag">micronutrients</span>
          <span class="search-tag">brain</span>
          <span class="search-tag">vitamin d</span>
          <span class="search-tag">vitamin c</span>
          <span class="search-tag">vitamin e</span>
          <span class="search-tag">vitamin b12</span>
          <span class="search-tag">vitamin k</span>
          <span class="search-tag">mortality</span>
          <span class="search-tag">aging</span>
          <span class="search-tag">omega-3</span>
          <span class="search-tag">biomarkers</span>
          <span class="search-tag">multivitamin</span>
          <span class="search-tag">cognition</span>
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        [Story] Chronic inflammation in early adulthood can impair cognitive performance by midlife, with 39% of young adults showing high inflammation levels.
      </h3>
</a>    <p>
      Research demonstrates that inflammation in later life harms the brain, increasing the risk of dementia and cognitive decline. However, scientists don&#39;t fully understand the effects of inflammation that begins in early adulthood. A recent study found that inflammation during early adulthood markedly impairs cognitive performance in midlife.
The research involved more than 2,300 young adults (aged 24 to 58) enrolled in the Coronary Artery Risk Development in Young Adults (https://www.cardia.dopm.uab.edu) study. Researchers tracked the participants&#39; inflammation levels, measured by C-reactive pro...
          <span class="search-tag">brain</span>
          <span class="search-tag">alzheimer&#39;s</span>
          <span class="search-tag">aging</span>
          <span class="search-tag">inflammation</span>
          <span class="search-tag">memory</span>
          <span class="search-tag">dementia</span>
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        [Story] Just two hours of daily screen time lowers psychological well-being and increases negative behaviors in preschool children.
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</a>    <p>
      Technology enriches our lives, enhancing communication, improving healthcare, and providing access to vast amounts of information. However, the amount of time we spend on the devices that deliver that technology may be harmful, especially for young children. A recent study found that two hours or more of daily screen time among preschoolers lowers psychological well-being. 
Researchers analyzed data from the 2018-2021 National Survey of Children&#39;s Health, focusing on children aged six months to five years. Primary caregivers reported the children&#39;s daily screen time and provided information ab...
          <span class="search-tag">technology</span>
          <span class="search-tag">behavior</span>
          <span class="search-tag">mental health</span>
          <span class="search-tag">development</span>
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        [Story] Activated charcoal drug can protect microbiome from antibiotics | New Scientist
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</a>    <p>
      A special slow-release formulation of activated charcoal can protect the gut microbiome from the harmful effects of antibiotics while still allowing the antibiotic to make its way to the bloodstream where it can fight infection (small clinical study).
This formulation is called DAV132 and coadministration of it with strong antibiotics dramatically reduced undesired intestinal antibiotic levels by over 99% without eliciting any adverse side effects. Importantly, they found that DAV132 did not impact plasma concentrations of the antibiotic, ensuring that antibiotics would still maintain full act...
          <span class="search-tag">microbiome</span>
          <span class="search-tag">antibiotics</span>
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        [Story] Antigen-specific immunotherapy: proteins like those that cause multiple sclerosis synthesized exogenously &amp; injected create self-tolerance
      </h3>
</a>    <p>
      FTA:
&amp;gt; [...] by synthesising proteins from the [myelin] sheaths in a lab, and then injecting them into the blood stream at increasing doses, the body begins to learn that they are safe.
&amp;gt; [...] “In allergies the immune system mounts a response to something like pollen or nuts because it wrongly believes they will harm the body.
&amp;gt; “But in autoimmune diseases the immune systems sees little protein fragments in your own tissue as foreign invaders and starts attacking them.
&amp;gt; “What we have found is that by synthesising those proteins in a soluble form we can desensitise the immune syst...
          <span class="search-tag">immune system</span>
          <span class="search-tag">multiple sclerosis</span>
          <span class="search-tag">protein</span>
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        [Story] Lactic acid protects against toxicity in Parkinson&#39;s disease. Lactic acid can cross BBB &amp; may explain why exercise helps. Parkinson&#39;s.
      </h3>
</a>    <p>
      FTA:
&amp;gt; Parkinson&#39;s disease affects neurons in the Substantia nigra brain region -- their mitochondrial activity ceases and the cells die. Researchers now show that supplying D-lactate or glycolate, two products of the gene DJ-1, can stop and even counteract this process. They also showed that the two substances rescued the toxic effects of the weed killer Paraquat. Cells that had been treated with this herbicide, which is known to cause a Parkinson&#39;s like harm of mitochondria, recovered after the addition of the two substances.
...
          <span class="search-tag">brain</span>
          <span class="search-tag">parkinson&#39;s</span>
          <span class="search-tag">tissue repair</span>
          <span class="search-tag">mitochondria</span>
          <span class="search-tag">neurons</span>
          <span class="search-tag">lactate</span>
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