Dr. Derya Unutmaz joins Dr. Rhonda Patrick to discuss how AI could extend lifespan, personalize cancer care, and transform medicine within a decade. ... technology genetic engineering diagnostics aging stem cells immune system cancer epigenetics brain
Watch nowSulforaphane, a compound generated from precursors found in cruciferous vegetables, has attracted interest for its potential effects on cancer biology. Researchers tested whether a supplement designed to generate sulforaphane in the body could alter tumor-related markers in men with prostate cancer. The double-blind study randomly assigned 41 men with prostate cancer awaiting surgery to remove the prostate to receive either a daily placebo or a broccoli-derived supplement containing 240 mg of glucoraphanin plus myrosinase for four weeks. Together, these ingredients generate sulforaphane after ... cancer prostate sulforaphane
Read moreProteins called Yamanaka factors can reprogram differentiated (mature) cells into pluripotent stem cells. However, scientists don’t fully understand the metabolic requirements underlying this process. A new study shows that vitamin B12 supports the metabolic processes involved in cellular reprogramming. First, researchers investigated how gut bacteria influence cellular reprogramming in mice. They induced gene expression to initiate reprogramming, and then they treated the mice with antibiotics to disrupt their gut microbiota. They found that reprogramming efficiency in the colon and stomach d... gut microbiome genetic engineering micronutrients vitamin b12
Read moreBlocking a key regulator of autoimmunity reduces the inflammation associated with multiple sclerosis. A protein found on the surface of some immune cells regulates autoimmunity in multiple sclerosis, a new study has found. Blocking the protein's activity reduced the inflammation associated with the disease. Researchers studied the role that the aryl hydrocarbon receptor – a protein found on specific immune cells called T cells – plays in autoimmunity in a mouse model of multiple sclerosis. They bred mice that lacked the aryl hydrocarbon receptor and examined the effects its absence had on T ... brain gut microbiome multiple sclerosis autoimmunity
Read moreA 2020 study found that kidney disease increases the risk of having tiny brain hemorrhages called microbleeds. People with kidney disease were five times more likely to have microbleeds than those with normal kidney function. Researchers studied the effects of kidney disease on cultured brain endothelial cells and in mice. They also tracked the progression of microbleeds in people who had kidney disease or were healthy. They found that exposing the cells to urea – a byproduct of protein metabolism that builds up in the blood during kidney disease – damaged the endothelial cells' integrity, ... diabetes omega-3 blood-brain barrier
Read moreBranched chain amino acids ameliorate cognitive losses associated with brain injury. Approximately 1.5 million people living in the United States experience a traumatic brain injury (TBI) – a disruption in normal brain function caused by an external mechanical force – each year. TBI causes both acute and chronic effects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677116/), including cognitive dysfunction. Findings from a 2009 study suggest that a branched chain amino acid-rich supplement ameliorates TBI-associated cognitive dysfunction. The branched chain amino acids, which include leuc... brain diet
Read moreIntermittent fasting is a broad term that describes periods of fasting between meals, lasting several hours to days. Intermittent fasting increases ketone production because it uses stored fat as an energy source. It also activates genetic pathways associated with enhanced healthspan and longevity. Caloric restriction, which typically involves a 10 to 40 percent reduction in total caloric intake, activates similar pathways. Findings from a new study suggest that intermittent fasting is more effective than caloric restriction in activating klotho, a longevity gene, to improve long-term memory r... fasting memory ketogenic diet
Read moreExtra-virgin olive oil protects nerve cell structure and function, improves learning and memory, and reduces the amyloid-beta plaques and neurofibrillary tangles in the brain in mice genetically engineered to get Alzheimer's disease. The polyphenols in olive oil activate autophagy, which leads to the clearance of plaques and tangles in the brain. Last week, I interviewed an expert on autophagy and we discussed how one of the most important functions of it is to clear away protein aggregates. We also discussed some of the mechanisms by which various polyphenols a (such as those found in olive o... nutrition alzheimer's autophagy protein
Read moreFTA: > Understanding how the disease works is important to developing effective drugs that protect the brain and stop the progression of Parkinson's disease. Nitric oxide is an important molecule for our brain and the body. > "However, when nitric oxide is produced within the brain in excess by a protein called inducible nitric oxide synthase, neurons start dying," said Pahan. > "This study has become more fascinating than we thought," said Pahan. "After castration, levels of inducible nitric oxide synthase (iNOS) and nitric oxide go up in the brain dramatically. Interestingly, castra... brain parkinson's testosterone nitric oxide neurons protein
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