As brain cells age, their cleanup systems lose efficiency, allowing damaged parts and sticky proteins to build up. To address this, a new study tried to restore guanosine triphosphate (GTP), which fuels cargo transport and recycling inside cells, to see if this could slow or even reverse the decline in aging neurons. In neurons from healthy older mice and from a strain that develops Alzheimer-like changes, researchers tested whether a 24-hour treatment could restore GTP levels and improve waste processing. The treatment used two bioactive compounds: nicotinamide, a vitamin B3 derivative, and e... alzheimer's autophagy brain green tea neuron supplements
Read moreCAR-T, or chimeric antigen receptor T-cell therapy, is an immunotherapy approach that involves genetically modifying a person's own T cells so they can recognize and target specific proteins on cancer cell surfaces, enhancing the immune system's capacity to seek out and destroy malignant cells. CAR-T therapies have been successful against blood cancers, such as leukemia, lymphoma, or myeloma, but have largely failed with solid tumors. Now, a new study in mice demonstrates that CAR-T is effective against ovarian cancer, nearly doubling survival time. Researchers identified a unique carbohydra... cancer genetic engineering immune system
Read moreDelta-9-tetrahydrocannabinol – better known as THC – is the primary psychoactive compound found in cannabis. THC binds to endocannabinoid system receptors, eliciting a wide range of physical effects and producing the "high" associated with its use. A new study suggests that THC reverses brain aging in old mice. Researchers injected old mice with a microdose of THC that was roughly three to four orders of magnitude lower than a typical dose. Then, they assessed gene expression in the animals' hippocampal tissue at five days and five weeks post-treatment. After just five days, they found that ... brain aging cannabinoid neurogenesis
Read moreFrom the article: > We knew that blood cells produced BDNF,"[...] "We didn't know why it was produced in blood cells." > Dr. Hiroshi Urabe and Dr. Hideto Kojima, current and former postdoctoral fellows in Chan's laboratory respectively, looked for BDNF in the brains of mice who had not been fed for about 24 hours. The bone marrow-derived cells had been marked with a fluorescent protein that showed up on microscopy. To their surprise, they found cells producing BDNF in a part of the brain's hypothalamus called the paraventricular nucleus. > "We knew that in embryonic development, some ... brain obesity bdnf
Read moreCOVID-19 Q&A Series Part 1: Rhonda Patrick, Ph.D. addresses subscriber questions in this multi-part series. ... covid-19 vitamin d vitamin c virus melatonin sauna autoimmunity
Watch nowGlobal estimates indicate that more than half of all adults are either overweight or obese. Obesity carries many health risks because it impairs the body's immune response and creates a pro-inflammatory environment. In particular, being obese increases the disease severity of influenza infection. A recent study suggests that the impaired immune response commonly exhibited in people who are obese promotes the emergence of more virulent influenza strains. Influenza is a highly contagious respiratory infection caused by the influenza virus. More than 20,000 people die every year in the United St... obesity immune system protein
Read moreHealthy brain activity is achieved by maintaining a balance between neural excitation and inhibition. Impairment in this balance is related to many neurological and neurodegenerative disorders, including epilepsy, autism, Parkinson's, Alzheimer's, and schizophrenia. In Caenorhabditis elegans, a model organism for studying both the nervous system and aging, neural excitation increases with age and age-related cognitive decline, but lifespan increases with inhibition. A recent study demonstrates that extended longevity in humans is associated with lower levels of genes related to neural excitati... brain aging stress protein
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