[toc position='left'] Consider a drug capable of reversing the effects of aging on the heart, restoring its youthful function. That's what researchers observed when they gave dogs rapamycin—a drug traditionally used to treat certain cancers and prevent organ transplant rejection. The findings were striking: The dogs exhibited marked improvements in heart function, effectively reversing the age-related changes typically seen in aging. While these findings are remarkable, they add to a growing body of research indicating that rapamycin might enhance healthspan and promote longevity in various sp... aging autophagy metabolism immune system cancer drug
Read more[toc position='left'] Introduction Light has profound and diverse effects on the human body, influencing sleep-wake cycles, circadian rhythmicity, mood, and immune function. In recent decades, scientists have begun exploiting the body's responses to light with photobiomodulation, a non-invasive, light-based therapeutic technique. Photobiomodulation employs specific wavelengths of light (measured in nanometers, nm) to stimulate biological processes within cells and tissues, triggering a cascade of physiological responses. A growing body of evidence suggests that photobiomodulation has potential... bone skin brain depression arthritis
Read moreIn this clip, Rich Roll and Dr. Rhonda Patrick discuss how IGF-1 levels impact cancer risk. ... cancer aging insulin protein cardiovascular
Watch now[toc position='left'] Senescence is a response to stress in which damaged cells terminate normal growth cycles to prevent dysfunctional cells from reproducing. Senescence is a vital cellular process involved in embryonic development, wound healing, and cancer immunity; [ref doi='10.1242/dev.151837'] however, the accumulation of senescent cells is associated with diseases of aging such as cancer, cardiovascular disease, type 2 diabetes, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, sarcopenia, and glaucoma.[ref doi='10.1016/j.cell.2017.05.015'] [ref doi='10.3390/ijms19102937'] ... neurodegeneration senescence aging
Read more[toc position='left'] Background [tweetbox text='"Because BHB is involved in such foundational cellular functions as gene regulation, increasing BHB concentrations may be protective against a wide range of diseases."' tweet='"Because BHB is involved in such foundational cellular functions as gene regulation, increasing BHB concentrations may be protective against a wide range of diseases." https://www.foundmyfitness.com/topics/beta-hydroxybutyrate'] Beta-hydroxybutyrate (BHB) is an endogenous (i.e., produced by the body) ketone produced via the breakdown of fats during times of carbohydrate sc... butyrate exercise fasting aging ketosis
Read more[toc position='left'] A single layer of epithelial cells lines the entire digestive tract, facilitating the exchange of nutrients between the intestine and the bloodstream. This layer, referred to as the intestinal epithelium, must be permeable to nutrients yet impermeable to pathogens. [tweetbox text='"Increased intestinal permeability (also known as "leaky gut") allows pathogens to leak through the intestinal barrier and pass directly into the bloodstream, promoting inflammation."' tweet='"Increased intestinal permeability (also known as "leaky gut") allows pathogens to leak through the int... intestinal permeability butyrate gut microbiome polyphenol autoimmunity
Read moreExercise puts a demand on skeletal muscle cells to produce energy at a faster rate than at rest. To do this, the body increases the delivery of fats to the muscle mitochondria while increasing the mitochondrial capacity to metabolize fats, a process called beta-oxidation. Researchers of a new study aimed to illuminate the cellular mechanisms of mitochondrial fat metabolism following moderate intensity aerobic exercise. Mitochondria are cellular structures responsible for the production of energy in the form of adenosine triphosphate (ATP). The inner membrane of mitochondria possess a series of... exercise fat
Read more[toc position='left'] Brain-derived neurotrophic factor, or BDNF, is a growth factor relevant to aging, brain function, behavior, metabolism, energy expenditure, and satiety. BDNF serves as a cell signaling protein, plays vital roles in numerous signaling pathways associated with a variety of disorders ranging from depression, (https://www.foundmyfitness.com/topics/depression) schizophrenia, and addiction to obesity and diabetes, and may serve as a hormone. It is perhaps best known for its influence on the formation, growth, survival, and development of neurons and for its role in mediating th... exercise omega-3 meditation brain alzheimer's parkinson's fasting memory interesting
Read more[toc position='left'] Sirtuins are highly conserved enzymes that play key roles in healthspan and longevity in multiple organisms. They are linked to the regulation of a variety of metabolic processes, including the release of insulin, mobilization of lipids, response to stress, and modulation of lifespan.[ref doi='10.1016/j.tem.2013.12.001'] [ref doi='10.1016/j.bbapap.2009.11.021'] Sirtuins have been implicated in the pathophysiology of metabolic disorders such as type 2 diabetes; neurological disorders such as Parkinson’s disease; and many other conditions related to aging.[ref doi='10.3389/... aging heart disease circadian rhythm brain cancer inflammation fasting resveratrol
Read moreThis is the full minute-by-minute timeline for JRE #502. Click here to watch the video on YouTube (http://www.youtube.com/watch?v=DgSLkakMDfE). 00:02:42 (http://youtu.be/DgSLkakMDfE?t=00h02m42s) - Starts off by talking about kappa opioids (http://en.wikipedia.org/wiki/%CE%9A-opioid_receptor) and dynorphin (http://en.wikipedia.org/wiki/Dynorphin) and how you feel stress right before important events 00:04:24 (http://youtu.be/DgSLkakMDfE?t=00h04m24s) - Joe talks about how great you feel after a competition (fight) 00:05:35 (http://youtu.be/DgSLkakMDfE?t=00h05m35s) - Talks about how capsaicin (h... omega-3 depression insulin fatty liver vitamin a isothiocyanates antioxidant protein dairy blood sugar metabolic syndrome myrosinase
Read more