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        [Podcast] How to Solve Aging in America
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      Dr. Rhonda Patrick&#39;s testimony before the United States Senate Special Committee on Aging.
...
          <span class="search-tag">nutrition</span>
          <span class="search-tag">exercise</span>
          <span class="search-tag">obesity</span>
          <span class="search-tag">aging</span>
          <span class="search-tag">muscle</span>
          <span class="search-tag">policy</span>
          <span class="search-tag">ultra-processed foods</span>
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        [Story] Vitamin D Supplementation: A Review of the Evidence Arguing for a Daily Dose of 2000 International Units (50 µg) of Vitamin D for Adults in the General Population
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      Vitamin D deficiency is a public health problem, affecting 1 billion people worldwide. This review presents data from randomized controlled trials indicating that daily vitamin D supplementation of 2,000 international units (50 micrograms) prevents and treats vitamin D deficiency. The authors posit that long-term supplementation at this dose is deemed safe, with no significant safety concerns reported, even for those with sufficient baseline vitamin D levels.
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          <span class="search-tag">vitamin d</span>
          <span class="search-tag">micronutrients</span>
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        [Story] Vitamin D protects against high glucose-induced pancreatic β-cell dysfunction via AMPK- NLRP3 inflammasome pathway
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      Vitamin D protects pancreatic beta cells in type 2 diabetes. 
Chronic inflammation is a principal driver of many of the pathological processes that accompany type 2 diabetes, a metabolic disorder characterized by hyperglycemia (high blood glucose) and subsequent pancreatic beta cell dysfunction. Findings from a recent study suggest that vitamin D blocks activation of the NLRP3 inflammasome, preventing inflammation-driven impairment of pancreatic beta cells.  
The NLRP3 inflammasome is a large, intracellular complex that plays critical roles in immune function. Its activation triggers the relea...
          <span class="search-tag">vitamin d</span>
          <span class="search-tag">insulin</span>
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        [Story] Vitamin D and magnesium co-supplementation improves behavior and mental health in children with ADHD.
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      Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral condition. Characterized by inattention and/or hyperactive or impulsive behavior that interferes with functioning, learning, or development, ADHD affects as many as 7 percent of children (https://pubmed.ncbi.nlm.nih.gov/29033005/) and nearly 3 percent of adults (https://pubmed.ncbi.nlm.nih.gov/31675080/) worldwide. Findings from a study published earlier this year suggest that vitamin D and magnesium co-supplementation improves behavior and mental health in children with ADHD. 
A growing body of evidence suggests that ...
          <span class="search-tag">vitamin d</span>
          <span class="search-tag">adhd</span>
          <span class="search-tag">magnesium</span>
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        [Story] Vitamin D supplementation may help patients clear the SARS-CoV-2 virus.
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      COVID-19 is a respiratory illness caused by the SARS-CoV-2 virus. A growing number of studies have demonstrated the importance of vitamin D in regulating the immune system and controlling COVID-19 disease severity. Authors of a new study found that vitamin D supplementation shortened SARS-CoV-2 infection in vitamin D-deficient people. 
Vitamin D is a hormone that affects the expression of many genes important for immune function. Vitamin D deficiency is associated with greater risk of influenza and other respiratory infections. Unfortunately, one 2012 report (https://www.ncbi.nlm.nih.gov/pmc/a...
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        [Story] Caffeine was shown to increase the activity of an enzyme (called NMNAT2) that is known to protect against dementia.
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</a>    <p>
      There have been several associative studies that have found that caffeine consumption is associated with a 36% lower dementia risk.
But this study was an in-vitro study (meaning it was done in cultured cells) so it is too early to say whether drinking a cup of coffee will boost the activity of this enzyme in humans but hopefully, future studies will illuminate this. It is likely that there may be several different compounds present in coffee that may have a positive effect on cognitive function.
On a side note, retinoic acid (vitamin A) was also shown to boost the activity of this enzyme altho...
          <span class="search-tag">brain</span>
          <span class="search-tag">aging</span>
          <span class="search-tag">dementia</span>
          <span class="search-tag">caffeine</span>
          <span class="search-tag">vitamin a</span>
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        [Story] People with MS that took a high dose vitamin D for 6 months reduced inflammatory immune cells related to MS severity.
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</a>    <p>
      Every 5 ng/ml increase in blood vitamin D was associated with a 1% decrease in inflammatory T cells.
Note: 10,400 IU is actually a pretty high dose of Vitamin D! Many of these people were severely deficient to start with. In fact, MS has been linked to genetically low vitamin D...meaning a gene that converts vitamin D into active vitamin D hormone does not work well in many MS patients so they need an unusually high dose of vitamin D. While an ideal dose of Vitamin D may be hard to pin down because of individual variation, what IS known is a generally ideal level. Most studies seem to show a r...
          <span class="search-tag">vitamin d</span>
          <span class="search-tag">inflammation</span>
          <span class="search-tag">immune system</span>
          <span class="search-tag">vitamin a</span>
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        [Story] Supplementing with vitamin D2 decreased levels of vitamin D3 &amp; increased muscle damage after intense weight lifting.
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      Vitamin D2 (plant-based) and Vitamin D3 apparently have a very important difference when it comes to athletes. Vitamin D2 worsens muscle damage post exercise, vitamin D3 enhances recovery. It is possible that the D2 inhibits or competes for an enzyme that is required to produce D3. The mechanism is not known but what is clear is that taking large doses of D2 does lower D3 levels and this leads to more muscle damage post intense workout.
Link to full publication. (https://www.mdpi.com/2072-6643/6/1/63)
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          <span class="search-tag">vitamin d</span>
          <span class="search-tag">exercise</span>
          <span class="search-tag">vitamin a</span>
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