[toc position='left'] Epigenetic aging clocks are among the most important tools in modern longevity science. They attempt to answer a deceptively simple question: can we measure how fast a person is aging biologically, rather than just counting the number of years they have been alive? The answer is yes—but with important caveats. Epigenetic clocks use patterns of DNA methylation, a chemical tagging system on DNA, to estimate different aspects of aging. Some clocks estimate chronological age. Others predict disease risk, mortality risk, or the current pace of biological aging. This means biol... epigenetics aging telomeres genetics stem cells omega-3 dna damage biomarkers vitamin d senescence multivitamin
Read moreDr. Rhonda Patrick and Dr. Steve Horvath discuss how epigenetic clocks measure biological age and which proven interventions actually slow or reverse aging. ... epigenetics telomeres genetics stem cells omega-3 dna damage biomarkers aging vitamin d senescence multivitamin
Watch nowNon-alcoholic fatty liver disease (NAFLD), now usually termed metabolic dysfunction-associated steatotic liver disease (MASLD), affects about one in four people worldwide and can progress to serious liver injury and even liver cancer. Because there are only limited pharmacologic options to prevent its progression, researchers are also looking closely at diet and supplements as possible tools. A new large study examined whether people who regularly take fish oil supplements face a lower risk of developing severe forms of this disease. Using data from the UK Biobank, investigators followed 488,... fatty liver omega-3
Read moreOmega-3 fatty acids play critical roles in maintaining brain health and function, potentially reducing the risk of developing Alzheimer's disease. People who carry the APOE4 gene variant and those with obesity have a higher risk of developing the disease, suggesting that differences in metabolism could be a factor. A 2022 study found that obesity influenced the amount of omega-3 in plasma phospholipid form that is important for brain transport. Fifty people (half of whom carried the APOE4 gene) took 2.5 grams of combined docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) daily for six ... brain alzheimer's obesity omega-3 genetics dementia
Read more...of potentially unreliable biomarkers, a factor that may produce hard-to-interpret results. Long-term measure of omega-3 intake [tweetbox text='"[The Omega-3 Index] really is just a risk factor like cholesterol, except this is one that you can modify easily...you can just eat more fish or take supple... cancer depression mortality omega-3 nutrition brain diet aging immune system mental health development intelligence
Read moreCellular DNA is subject to tens of thousands of injuries each day that arise from both endogenous sources, such as free radicals produced during normal metabolism, and exogenous sources, such as cytotoxic drugs, ionizing radiation, and cigarette smoke, among others. DNA damage induces genomic instability, a hallmark of aging (https://www.foundmyfitness.com/topics/hallmarks-of-aging). Evidence from a 2020 study suggests that omega-3 fatty acids protect against DNA damage. The study involved 140 healthy children and adolescents (aged 9 to 13 years). Researchers assessed the children's body meas... omega-3 dna damage
Read more...educe inflammation. Learn more about omega-3s and brain health in our comprehensive overview article. (https://www.foundmyfitness.com/topics/omega-3) Omega-3 Index validation: The Omega-3 Index is a biomarker of omega-3 fatty acids in red blood cells, providing a more accurate assessment of omega-3 s... omega-3 immune system blood-brain barrier brain alzheimer's gut obesity
Read moreLong-chain omega-3 fatty acids, such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), increase serum testosterone levels in mice, although the mechanisms that drive these benefits are unclear. While omega-3 fatty acids improve cellular function, omega-6 fatty acids serve as precursors to pro-inflammatory cytokines, such as arachidonic acid, which damage cells. Findings from a recent report detail the effects of long-chain omega-3 fatty acids and omega-6 fatty acids on serum testosterone levels in adults with overweight and obesity. Omega-3 fatty acids are essential nutrients foun... omega-3 testosterone
Read moreDr. Dale Bredesen discusses treatments that may reverse symptoms of mild cognitive decline and Alzheimer’s disease. ... alzheimer's brain diet aging hormones insulin resistance inflammation dementia insulin
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