When a tooth infection spreads to the root, the body's immune response can become overly aggressive, destroying surrounding bone and tissue. Scientists at São Paulo State University tested whether two accessible lifestyle factors, swimming and omega-3 fatty acids, could reduce this damage. Thirty male rats were divided into three groups: an exercise‑only group, a group that combined exercise with omega-3 supplementation, and a control group without exercise or omega-3 supplementation. The exercising rats swam for an hour a day, five days a week, for six weeks. The combined group also received... exercise omega-3 dental
Read moreDr. Peter Attia presents practical steps we can implement to improve our health, emphasizing the importance of each aspect while providing actionable advice. ... aging cancer metabolism
Watch nowAlthough inflammation is a critical component of the body's immune response, excess inflammation drives many chronic diseases, such as autoimmune disorders, cardiovascular diseases, diabetes, and cancer. A new study in mice shows that regular exercise reprograms macrophages, altering how they sense and respond to pathogens and reducing inflammation. Macrophages are immune cells that participate in pathogen elimination via phagocytosis. Distinguished by their polarization, "M1" macrophages exhibit a proinflammatory phenotype, while "M2" macrophages exhibit an anti-inflammatory phenotype. A hig... exercise inflammation immune system mitochondria
Read moreThis 2023 study found that exercise dampened inflammatory pathways and restored immune function in old animals. ... exercise aging inflammation stem cells
Read moreLactate is a compound that is produced primarily in the muscles via the breakdown of glucose during exercise. It can be "shuttled" from the muscles to various tissues, including the heart, and brain, where it can be used as an energy source. Evidence from a recent study suggests that lactate rejuvenates immune cells that target cancer. Specialized immune cells called CD8+ T cells are the primary drivers of anti-tumor immunity. During cancer progression, CD8+ T cells can experience "exhaustion," (https://www.frontiersin.org/articles/10.3389/fimmu.2020.622509/full) a dysfunctional state caused ... exercise cancer lactate
Read moreFrom the article: >Another Reason to Work Out Results showed that the ratio of senescent to naïve T cells changed favorably in the majority of participants, with most of the study subjects regaining greater numbers of the naïve variety. >"What we're suggesting is that with exercise, you might be getting rid of T cells that aren't helpful and making room for T cells that might be helpful," Bilek says. ... exercise cancer immune system
Read moreEffect of aerobic exercise on cancer in mice: > Training mice regularly on a wheel (the mouse version of a treadmill) decreased the growth of multiple types of tumors, including skin, liver, and lung cancers. Furthermore, mice that exercised regularly had a smaller chance of developing cancer in the first place. The beneficial effects of running went beyond tumor formation and growth, extending to cancer-associated weight loss, a process termed cachexia that is seen in cancer patients. Mice that exercised regularly showed no signs of cancer-associated weight loss in the researchers' lung ca... exercise cancer immune system aerobic il-6
Read moreRhonda explains NAD+: importance for aging, decline with age, boosters (nicotinamide riboside, nicotinamide mononucleotide), and data in animals and humans. ... aging dna damage genetics resveratrol
Watch nowSeveral studies have established causation showing that sleep duration is a major determinant of insulin sensitivity. ... sleep exercise obesity metabolism diabetes insulin resistance
Watch nowFrom the article: > BHB is a metabolite produced by the body in response to fasting, high-intensity exercise, caloric restriction, or consumption of the low-carbohydrate ketogenic diet. Dixit said it is well known that fasting and calorie restriction reduces inflammation in the body, but it was unclear how immune cells adapt to reduced availability of glucose and if they can respond to metabolites produced from fat oxidation. > Working with mice and human immune cells, Dixit and colleagues focused on how macrophages -- specialized immune cells that produce inflammation -- respond when ex... exercise diet ketosis inflammation fasting immune system nlrp3 ketogenic diet
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