As brain cells age, their cleanup systems lose efficiency, allowing damaged parts and sticky proteins to build up. To address this, a new study tried to restore guanosine triphosphate (GTP), which fuels cargo transport and recycling inside cells, to see if this could slow or even reverse the decline in aging neurons. In neurons from healthy older mice and from a strain that develops Alzheimer-like changes, researchers tested whether a 24-hour treatment could restore GTP levels and improve waste processing. The treatment used two bioactive compounds: nicotinamide, a vitamin B3 derivative, and e... alzheimer's autophagy brain green tea neuron supplements
Read moreAging compromises muscle strength and bone density, altering the signaling pathways that coordinate their function. These pathways involve myokines—hormone-like proteins released by muscle during exercise that help regulate metabolism, enhance muscle performance, and support bone formation. A recent study found that levels of a myokine called cardiotrophin-like cytokine factor 1 decline sharply with age but rise by nearly 70% following resistance exercise in both humans and mice. Researchers measured cardiotrophin-like cytokine factor 1 levels in muscle and blood samples from young and older a... aging bone exercise muscle
Read moreDr. Patrick's keynote: compromised intestinal barrier affects human health—cardiometabolic function, neurological health, behavior, and more. ... intestinal permeability alzheimer's gut heart disease inflammation depression blood-brain barrier lipopolysaccharide
Watch nowDr. Bill Harris discusses the roles that omega-3 fatty acids play in cardiovascular and neurocognitive health. ... omega-3 brain aging heart disease biomarkers inflammation immune system pregnancy mortality polyunsaturated fat
Watch nowInflammatory bowel diseases, a group of conditions characterized by chronic inflammation of the digestive tract, affect the lives of nearly seven million people worldwide. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease. A report published in 2020 describes a wearable device that detects the presence of biomarkers associated with inflammatory bowel diseases in sweat, potentially signaling a symptom flare. A common feature of many inflammatory bowel diseases are periods of remission and relapse, often referred to as "flares." During flares, interleuki... technology gut inflammation
Read moreComprehensive overview: Breast milk's nutritional and non-nutritional components, and health benefits for mother and infant through breastfeeding ... development brain microbiome omega-3 alcohol behavior caffeine allergies tobacco
Watch nowDr. David Sinclair discusses the mechanisms that drive human aging and the importance of identifying ways to slow or reverse aging's effects. ... aging epigenetics dna damage stem cells genetics resveratrol
Watch nowDr. Matthew Walker discusses the role of sleep in immunity, creativity, and aging. ... sleep brain alzheimer's cancer obesity aging performance depression immune system stress circadian rhythm behavior dementia
Watch nowFrom the article: > The new research focuses on the impact that traumatic brain injury has on the glymphatic system. It has been long observed that the protein tau plays an important role in the long-term damage sustained by the brain after a trauma. Tau helps stabilize the fibers, or axons, that nerve cells send out to communicate with their neighbors. > However, during trauma, large numbers of these proteins are shaken free from the axons to drift in the space between the brain's cells. Once unmoored from nerve cells, these sticky proteins are attracted to each other and, over time, fo... brain alzheimer's parkinson's performance concussion protein neurodegeneration blood-brain barrier
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