We often think of aging as a steady, downhill slope, but a new study suggests aging happens in two distinct bursts—in our mid-40s and again around age 60—when massive shifts in crucial molecules involved in metabolism and other critical processes occur. These shifts may explain why our disease risk and other hallmarks of aging tend to spike at these pivotal times in our lives. The study involved 108 adults aged 25 to 75 years living in the U.S. Researchers assessed changes in 135,000 molecular markers in the participants' blood, feces, and bodily fluids for up to seven years, yielding more tha... aging metabolism immune system cardiovascular
Read moreDr. Luc van Loon discusses optimal protein intake & distribution strategies for stimulating muscle protein synthesis. ... protein muscle cold stress supplements
Watch nowHigher omega-3 fatty acid consumption could play a unique role in mitigating chronic inflammation by altering the methylation pattern of the interleukin-6 (IL-6) promoter, reducing the activity of this inflammatory cytokine. This epigenetic mechanism highlights omega-3's capacity to govern gene expression and shape the genetic landscape, transcending its contributions to cell membrane dynamics or mediator production and positioning its effects at the molecular blueprint level rather than merely fine-tuning cellular responses. The relationship between IL-6 and human health is multifaceted: Inte... omega-3 inflammation genetics
Read moreNSAIDs may promote a paradoxical pro-inflammatory effect, increasing the risk of blood clots and cardiovascular events. Non-steroidal anti-inflammatory drugs, or NSAIDs, are among the most widely used drugs worldwide, available in both prescription and over-the-counter forms, such as aspirin, ibuprofen, naproxen, and others. Despite the drugs' anti-inflammatory effects, their chronic use is associated with a higher risk of acute clot-related cardiovascular events, such as heart attack, stroke, or deep-vein thrombosis. Authors of a 2005 article posited that NSAIDs induce a rebound effect that ... heart disease inflammation nsaid cardiovascular
Read moreSerious neuropsychiatric disorders increase the risk of dying from cardiovascular disease. People who have serious neuropsychiatric disorders, such as bipolar disorder, schizophrenia, or schizoaffective disorder, are more likely to die of premature causes than their peers, often as much as 10 to 20 years earlier (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461039/). Findings presented in a recent report suggest that people with serious neuropsychiatric disorders have an increased risk of dying from cardiovascular disease. Cardiovascular disease is a large class of diseases that involve the... heart disease mental health cardiovascular
Read moreCancer is the second leading cause of death among people living in the United States, having claimed the lives of more than 600,000 people in 2020. Lifestyle behaviors, such as poor dietary habits, smoking, and physical inactivity, are key drivers of many cancers (https://link.springer.com/article/10.1007/s11095-008-9661-9). Findings from a recent study suggest that more than 46,000 cancer deaths could be prevented every year if people met current physical activity guidelines. Physical activity is a broad term that describes both daily activities, such as gardening, doing household chores, or... exercise cancer
Read moreTraditionally, governments and public health authorities have placed a high emphasis on recommending physical activity as a means of combating weight gain and obesity. Yet, randomized controlled trials have found exercise alone to have a relatively modest effect on body weight, yielding weight loss averages in the order of 4 (https://pubmed.ncbi.nlm.nih.gov/21787904/) to 11 (https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/215659) pounds (2 to 5 kilograms) in people with overweight and obesity. Some researchers have posited that metabolic adaptation (https://pubmed.ncbi.nlm.ni... exercise obesity metabolism
Read moreMetabolic syndrome is a constellation of conditions that includes high blood pressure, high blood glucose, excess abdominal fat, and abnormal cholesterol levels. People with metabolic syndrome are at higher risk for developing heart disease, stroke, and type 2 diabetes. Findings from a new study suggest that fasting "jump starts" dietary strategies to improve symptoms of metabolic syndrome. The "Western diet," also known as the Standard American Diet, is rich in processed foods, red meat, high-fat dairy products, and added sugars. It plays contributing roles in the development of metabolic sy... microbiome fasting blood pressure
Read moreDr. Rhonda Patrick makes her eighth appearance on the Joe Rogan Experience. ... nutrition alzheimer's diet microbiome sleep ketosis omega-3 fasting micronutrients multiple sclerosis nsaid sauna
Watch nowDr. Rhonda Patrick makes her second appearance on the Joe Rogan Experience. ... rhonda vitamin d nutrition brain diet obesity epigenetics aging sleep dna damage vitamin e sauna
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