Vitamin D and estradiol may synergistically help protect against metabolic syndrome. (2019)
From the article:
Metabolic syndrome has emerged as a major public health concern, affecting 30% to 60% of postmenopausal women worldwide.
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The cross-sectional study included 616 postmenopausal women aged 49 to 86 years who were not taking estrogen and vitamin D/calcium supplements at the beginning of the trial. It concluded there was a positive correlation between vitamin D and estradiol.
Specifically, higher vitamin D was associated with a favorable lipid profile, blood pressure, and glucose level. Estradiol was negatively associated with cholesterol, triglycerides, and blood pressure. These results suggest a synergistic role of vitamin D and estradiol deficiency in developing metabolic syndrome in postmenopausal women.