Hypertension in combination with APOE4 dramatically increases risk of high amyloid burden, possibly by increasing penetration of blood-brain barrier

www.sciencedaily.com

From the article:

Based on evidence that hypertension was associated with Alzheimer’s disease, Rodrigue suspected that the combination of hypertension and the presence of the APOE-e4 gene might lead to particularly high levels of amyloid plaque in healthy adults.

[…]

The most striking result of the study was that nonmedicated hypertensive adults who also carried a genetic risk factor for Alzheimer’s disease showed much higher amyloid levels than all other groups. Adults with medication-controlled hypertension, even those with genetic risk, had levels of amyloid plaque equivalent to participants without hypertension or genetic risk.

Unlock the Science Digest — our exclusive biweekly newsletter featuring the latest scientific discoveries, concise summaries, and Rhonda's expert commentary. Available only to FoundMyFitness Premium Members.

Choose a monthly subscription in
any eligible amount
Already have an account? Log in
Monthly
Save 20%
Yearly