Seven days of exposure to acetominophen reduced testosterone by 45% in mouse model of in utero testicular development
From the article:
The University of Edinburgh study tested the effect of paracetamol on testosterone production in mice that carried grafts of human testicular tissue. These grafts have been shown to mimic how the developing testes grow and function during pregnancy.
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Scientists gave the mice a typical daily dose of paracetamol – over a period of either 24 hours or seven days. They measured the amount of testosterone produced by the human tissue an hour after the final dose of paracetamol.
They found there was no effect on testosterone production following 24 hours of paracetamol treatment. After seven days of exposure, however, the amount of testosterone was reduced by 45 per cent.