Estradiol use may be associated with a lower risk of blood clot formation in the leg veins and lungs than conjugated equine estrogen use. (2013)

www.sciencedaily.com

From the article:

To further understand the differences in risk, the researchers also measured clotting (coagulation) factors in the blood of women who did not develop a clot. The researchers found that, compared with estradiol users, conjugated equine estrogen users had levels of blood factors that made them more prone to form blood clots.

The researchers also investigated other cardiovascular events:

– The risk of having a heart attack was somewhat – but not significantly – higher in women using oral conjugated equine estrogens than in those using oral estradiol.

– No difference was seen in the risk of stroke.

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