Orally administered vitamin C with an average dose of 2 grams per day reduced the length of ICU stay on average by 8.6%
From the article:
Vitamin C metabolism is changed in many conditions that involve physiological stress, such as infections, surgery, traumas, and burns, in which case vitamin C levels can decline dramatically. Although 0.1 grams per day of vitamin C can maintain a normal plasma level in healthy persons, much higher doses, up to 4 grams per day, are needed for critically ill patients to increase their plasma vitamin C levels to the range of normal healthy people. Therefore, high vitamin C doses may be needed to compensate for the increased metabolism in critically ill patients.
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Dr. Harri Hemilä from the University of Helsinki, Finland, and Dr. Elizabeth Chalker from the University of Sydney, Australia, carried out a systematic review of vitamin C for ICU patients. They identified 18 relevant controlled trials, and 12 of them were included in the meta-analysis on the length of stay. On average, vitamin C administration shortened ICU stay by 7.8%. In six trials, orally administered vitamin C with an average dose of 2 grams per day reduced the length of ICU stay on average by 8.6%.