Mitochondrial bioenergetics
Yamanaka factors
Exercise intensity
Cell reprogramming
Blood-brain barrier
Epigenetic age deceleration
Stress resistance
Cardiorespiratory fitness
Nutritional ketosis
Compression of morbidity
CpG Islands
Lactate shuttle
Whole-body hyperthermia
Psychology of grit
Telomerase reverse transcriptase (TRT)
Chronic inflammation
Disease prevention
Therapeutic hyperthermia
Pathogen-host defense theory
Cell signaling
Proteostasis
Cellular senescence
CRISPR-Cas9
Aging
PGC1α
Overcoming adversity
Increased healthspan
Gene–diet interaction
Biology of resilience
Immune-brain interaction
Neuroendocrine effects
Heat Shock Proteins (HSPs)
Oxidative stress
Vitamin D
Omega-3 fatty acids
β-Hydroxybutyrate (BHB)
GLUT4
Pregnancy optimization
A newsletter by Dr. Rhonda Patrick, exploring the science of stress resilience, disease prevention, and living a more fulfilled life — rooted in biology and inspired by her podcast.
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A science-driven newsletter calibrated to enhance your well-being incrementally — because better decisions compound over time.
Each installment provides tactical insight on micronutrients, aging, sleep, and resilience to drive meaningful, measurable outcomes.
What experts are saying
Popular Topics
Vitamin C
Vitamin C is an essential nutrient, widely recognized for its antioxidant properties and its roles in many critical processes and pathways.
Alcohol
Alcohol is one of the most widely used and abused drugs and is associated with several health conditions.
Omega-3 fatty acids
Omega-3 fatty acids play critical roles in human health and may be beneficial in ameliorating symptoms associated with chronic health conditions and in combating aging-related diseases.
Zinc
Zinc is an essential nutrient that influences growth and development and plays critical roles in immune function, protein synthesis, wound healing, DNA synthesis, and cell division.
Brain-derived neurotrophic factor (BDNF)
BDNF is a growth factor known for its influence on neuronal health and for its role in mediating the beneficial cognitive effects associated with exercise.
Sauna
Sauna use exposes the body to extreme heat and, in turn, induces protective responses that improve health and may increase healthspan.