Dr. Rhonda Patrick and Dr. Arthur Brooks explore the science of happiness and how to live a more meaningful life. ... mental health anxiety social media stress behavior meditation dopamine brain depression
Watch now[toc position='left'] Introduction Omega-3 fatty acids are polyunsaturated fats that play critical roles in human health, participating in a wide range of biochemical pathways and processes and modulating the expression of genes throughout the lifespan. Omega-3 fatty acids include plant-derived alpha-linolenic acid (ALA) and marine-derived eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), among others. A growing body of evidence indicates that omega-3 fatty acids may prevent or ameliorate symptoms associated with chronic health conditions such as cardiovascular disease,[ref doi='10.3... cancer depression mortality omega-3 nutrition brain diet aging immune system mental health development intelligence
Read more[toc position='left'] Toll-like receptors are a family of pattern recognition receptors expressed on the surface of immune and other cells. Toll-like receptors are the principal inducers of innate immunity[ref doi='10.1186/cc1471'], activating transcription factors such as NF-kB that increase the expression of inflammatory cytokines. Among toll-like receptors, TLR4 is notable for recognizing lipopolysaccharide (LPS), a structure found on the outer membranes of Gram-negative bacteria. This overview will predominantly focus on TLR4 and its involvement in human health, disease, and behavior. Toll... toll-like receptors gut aging microbiome inflammation immune system intestinal permeability omega-3 endotoxemia
Read moreClumps of APOE protein present in the brains of people with Alzheimer's disease. Alzheimer’s disease is a neurodegenerative disorder characterized by progressive memory loss, spatial disorientation, cognitive dysfunction, and behavioral changes. A defining pathological feature of Alzheimer's disease is the presence of misfolded proteins – specifically amyloid-beta and tau – that form clumps (called aggregates) in the brain. A recent study identified aberrant clumps of misfolded apolipoprotein E (APOE) protein in the brains of people who had Alzheimer's disease. Proteins are long chains of pe...
Read more[toc position='left'] Introduction Lactobacillus reuteri is a bacterium found in the digestive tracts of mammals, including humans, and in fermented foods. It is a member of the genus Lactobacillus, which comprises most of the bacteria that live on and in the human body. Lactic acid-producing bacteria, such as those in the Lactobacillus genus, are commonly used in probiotic supplements.[ref doi='10.1016/j.tim.2021.01.003'] Furthermore, some online resources provide step-by-step instructions for at-home bulk production of yogurt with L. reuteri enrichment. (https://drdavisinfinitehealth.com/201... gut probiotics microbiome
Read moreThe delta variant of SARS-CoV-2, the virus that causes COVID-19, is one of multiple variants to exhibit increased resistance to antibodies as well as higher transmissibility. It is unclear if vaccination or prior infection with the original Wuhan Hu-1 strain is effective against these emerging variants. But now, a new report suggests individuals who have recovered from infection with the original SARS-CoV-2 strain are protected from variants such as delta, especially following vaccination. A virus strain is considered the "parent" form of a virus. For example, SARS-CoV-1 and SARS-CoV-2 are str... vaccine covid-19
Read moreOn December 18, 2020, the Food and Drug Administration granted emergency use authorization (https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/moderna-covid-19-vaccine) for the Moderna mRNA vaccine against SARS-CoV-2, the virus that causes COVID-19. In recent weeks, however, variants of the SARS-CoV-2 virus have emerged, raising questions about the vaccine's efficacy. A recent report from Moderna summarizes their findings regarding the two variants. To be considered a variant, a virus must have sufficient mutations to change a portion of its genetic code... covid-19
Read moreAlzheimer’s disease is a neurodegenerative disorder characterized by progressive memory loss, cognitive decline, and behavioral changes. Roughly 50 million people have Alzheimer's disease worldwide (https://www.who.int/news-room/fact-sheets/detail/dementia). Researchers have developed a blood test that measures phospho-tau217 (p-tau217), a type of tau protein, and may be useful in diagnosing Alzheimer's disease as early as 20 years before symptoms manifest. Tau is a protein that clumps together and forms tangles inside neurons in the brains of people with Alzheimer's disease. When tau tangles... alzheimer's
Read more[toc position='left'] Depression is a neuropsychiatric disorder characterized by negative mood, loss of interest in doing things, and metabolic, hormonal, and immune disturbances that can degrade a person's quality of life and increase their risk of disease and death. The World Health Organization estimates that approximately 322 million people – more than 4 percent of the global population – currently live with depression,[ref doi='10.1001/jama.2017.3826'] the most common mental health disorder worldwide. Between 2005 and 2015 (the most recent years for which robust meta-analyses are availabl... inflammation probiotics circadian rhythm meditation behavior heat stress depression metabolism neurotransmitter nutrition exercise brain microbiome interesting omega-3
Read moreThis is the full minute-by-minute timeline for JRE #502. Click here to watch the video on YouTube (http://www.youtube.com/watch?v=DgSLkakMDfE). 00:02:42 (http://youtu.be/DgSLkakMDfE?t=00h02m42s) - Starts off by talking about kappa opioids (http://en.wikipedia.org/wiki/%CE%9A-opioid_receptor) and dynorphin (http://en.wikipedia.org/wiki/Dynorphin) and how you feel stress right before important events 00:04:24 (http://youtu.be/DgSLkakMDfE?t=00h04m24s) - Joe talks about how great you feel after a competition (fight) 00:05:35 (http://youtu.be/DgSLkakMDfE?t=00h05m35s) - Talks about how capsaicin (h... omega-3 depression insulin fatty liver vitamin a isothiocyanates antioxidant protein dairy blood sugar metabolic syndrome myrosinase
Read more