Calorie restriction does more than reduce body fat; it also changes how cells maintain and repair themselves. Researchers investigated whether semaglutide, a GLP-1 receptor agonist widely used for weight loss, could reproduce some of those effects when given late in life. The experiments began in female mice at 20 months of age. One randomized comparison followed 40 mice receiving daily semaglutide and 39 receiving inactive saline injections until their death. Separate mice underwent three months of treatment before tests of memory, physical abilities and glucose control, alongside cellular s... inflammation diabetes neurons weight loss neurogenesis neurodegeneration GLP-1 exercise cognition
Read moreAging compromises muscle strength and bone density, altering the signaling pathways that coordinate their function. These pathways involve myokines—hormone-like proteins released by muscle during exercise that help regulate metabolism, enhance muscle performance, and support bone formation. A recent study found that levels of a myokine called cardiotrophin-like cytokine factor 1 decline sharply with age but rise by nearly 70% following resistance exercise in both humans and mice. Researchers measured cardiotrophin-like cytokine factor 1 levels in muscle and blood samples from young and older a... aging bone muscle exercise
Read moreProtein misfolding in the brain is a central player in both aging and Alzheimer's disease, driving toxic protein buildup and brain cell dysfunction. However, evidence indicates that ketones—a critical brain fuel produced during fasting or exercise—may help reduce or prevent this damage. A recent cell study found that beta-hydroxybutyrate, a type of ketone, helps protect the brain by targeting toxic proteins for disposal. Researchers delivered beta-hydroxybutyrate to brain cells collected from mice and monkeys via an exogenous ketone ester. They examined the cells for changes in protein solubi... ketosis alzheimer's dementia ketogenic diet protein diet brain
Read moreProteins in milk, meat, and other foods can trigger allergic reactions in some people. However, these proteins—called antigens—can also interact with the immune system to suppress small intestinal tumors. A recent study in mice found that food antigens help activate immune responses in the small intestine, potentially reducing the risk of tumors. Researchers fed mice genetically prone to developing intestinal tumors—similar to the genetic predisposition to familial adenomatous polyposis in humans—an antigen-free diet to pinpoint the role of food components in immune activation. They also depl... cancer diet immune system allergies protein
Read moreDr. Morgan Levine discusses epigenetics and the application of epigenetic aging clocks in quantifying human aging. ... epigenetics cancer aging inflammation senescence
Watch nowStroke is one of the leading causes of death and disability worldwide, claiming the lives of roughly 5 million people and leaving another 5 million permanently disabled every year. A 2013 study demonstrated that sulforaphane protects the brain during ischemic stroke via hormetic preconditioning. Ischemic stroke occurs when blood flow to the brain is reduced or interrupted, starving neurons of oxygen and nutrients. Neuronal death occurs in the immediate area of a stroke within the first few hours of the incident, but nearby cells can be rescued with appropriate therapies. Heme oxygenase-1 (HO-... brain sulforaphane stroke nrf2
Read moreA new study found that daily heat treatments applied locally to muscle during 10 days of immobilization prevented the loss of mitochondrial function, increased heat shock protein levels, and attenuated skeletal muscle atrophy by 37% compared to sham control in a small trial in humans. I am really glad to see this replicated now in humans. There’s were two similar studies that I covered in past videos, which showed that whole body heat treatment (similar to a sauna) prevented muscle atrophy and increased muscle regrowth after immobilization, however, these were done in mice. The difference is t... heat stress muscle sauna protein dairy
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