Weight loss can look successful on the scale while concealing whether the body lost fat or muscle. Researchers tested whether raising ketone levels during treatment with semaglutide, the weight-loss drug sold under brand names such as Ozempic and Wegovy, could protect skeletal muscle without interfering with fat loss. Male mice with diet-induced obesity and poor blood sugar control entered a three-week rapid-weight-loss experiment as they switched from a high-fat diet to regular food under calorie-deficit conditions. They were randomly assigned to inactive saline control injections, semaglutid... Exogenous ketones fat GLP-1 ketosis muscle weight loss
Read moreExercise has long been linked to better immune health, but much less is known about what happens inside individual immune cells as fitness increases. A new study examined how cardiorespiratory fitness is linked to energy use and signaling in cytotoxic T cells, immune cells that help destroy infected or abnormal cells. The study included 43 healthy adults aged 20 to 40. Each participant completed a demanding cycling test to estimate their aerobic fitness, meaning how well the body delivers and uses oxygen during hard exercise. Using resting blood samples, researchers analyzed cytotoxic T cells ... exercise immune system
Read moreHydrogen sulfide is a small signaling molecule that the body produces using sulfur-containing compounds. It helps cells respond to stress, generate energy, and regulate how proteins function. Researchers wanted to know whether increasing production of this molecule over time could promote healthy aging. The study included a long-term lifespan experiment in healthy male mice starting at 20 weeks of age. Their diet was supplemented with a garlic-derived mixture of diallyl sulfur compounds (molecules with two small carbon-containing "arms" linked by sulfur atoms). To isolate the role of individu... aging metabolism
Read moreDr. Rhonda Patrick and Dr. Charles Brenner discuss NAD precursors, NR versus NMN, NAD IV drips, and what truly boosts NAD for recovery and longevity. ... nad+ pregnancy dna damage aging resveratrol oxidative stress
Watch nowInflammation and depression are often linked, particularly in older adults, who tend to experience chronic low-grade inflammation and elevated rates of depression. A recent study found that anti-inflammatory interventions may help reduce symptoms of depression and the risk of developing depression in older adults. Researchers conducted a systematic review and meta-analysis of 31 randomized, placebo-controlled trials that assessed the effects of anti-inflammatory therapies on depression in older adults. The various anti-inflammatory agents included omega-3 fatty acids, nonsteroidal anti-infla... omega-3 inflammation depression mental health nsaid polyphenol
Read moreIn my keynote at LongevityFest 2023, I share powerful habits to delay aging and improve healthspan, presented at the American Academy of Anti-Aging Medicine. ... aging vitamin d exercise omega-3 micronutrients magnesium bdnf
Watch nowPregnant women with obesity often experience high levels of inflammation. But a new study shows that omega-3s may reduce inflammation during pregnancy. Women with obesity who took omega-3 fatty acids during their pregnancies experienced a sixfold reduction in C-reactive protein, a marker of inflammation. The study involved 49 pregnant women with obesity. Half of the women took an omega-3 supplement providing 800 milligrams of docosahexaenoic acid (DHA) and 1,200 milligrams of eicosapentaenoic acid (EPA) daily, starting before week 16 of their pregnancies and continuing until delivery. The othe... obesity omega-3 inflammation pregnancy supplements crp
Read moreFrom the article: > Scientists have found that six weeks of intense exercise -- short bouts of interval training over the course of 20 minutes -- showed significant improvements in what is known as high-interference memory, which, for example, allows us to distinguish our car from another of the same make and model. [...] > They also found that participants who experienced greater fitness gains also experienced greater increases in brain-derived neurotrophic factor (BDNF), a protein that supports the growth, function and survival of brain cells. > "Improvements in this type of memory ... brain performance memory aerobic bdnf
Read moreDr. Dale Bredesen discusses treatments that may reverse symptoms of mild cognitive decline and Alzheimer’s disease. ... alzheimer's brain diet aging hormones insulin resistance inflammation dementia insulin
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