[toc position='left'] Biological aging clocks are among the most important tools in modern longevity science. They attempt to answer a deceptively simple question: can we measure how fast a person is aging biologically, rather than just counting the number of years they have been alive? The answer is yes—but with important caveats. Epigenetic clocks use patterns of DNA methylation, a chemical tagging system on DNA, to estimate different aspects of aging. Some clocks estimate chronological age. Others predict disease risk, mortality risk, or the current pace of biological aging. This means biol... epigenetics aging telomeres genetics stem cells omega-3 dna damage biomarkers vitamin d senescence multivitamin
Read moreDr. Rhonda Patrick and exercise physiologist Brady Holmer discuss a new study which challenges the current exercise guidelines. ... exercise mitochondria muscle aerobic cardiovascular bdnf metabolism exercise snacks
Watch now[toc position='left'] Choline is an essential nutrient critical for various bodily functions, including brain development, liver health, and muscle function. It acts as a precursor to acetylcholine, a neurotransmitter involved in memory, attention, and muscle control. Choline also contributes to the synthesis of phospholipid membranes and serves as a source of methyl groups necessary for metabolic processes. While the body can produce small amounts of choline, most of it must come from the diet to meet physiological needs. The benefits of choline are wide-ranging. During pregnancy, adequate ch... brain blood-brain barrier alzheimer's acetylcholine
Read more[toc position='left'] Introduction Microplastics are everywhere: in the food we eat, the water we drink, and even the air we breathe. Imagine consuming the equivalent of a credit card’s worth of plastic every week—just by going about your daily routine. As startling as it may seem, this is the reality we face, exposing our bodies to a hidden threat that’s growing by the day. What are microplastics? They're tiny pieces of plastic or other polymer-based materials, ranging from 5 millimeters (~0.2 inches) to as small as 100 nanometers, often called nanoplastics. These tiny particles contain a var... environment brain diet cardiovascular Microplastics pollution PFAS
Read more[toc position='left'] Polyphenols comprise a group of antioxidant compounds found in a variety of plants consumed as foods and beverages. Polyphenols are one of the most common classes of bioactive compounds found in plants, along with alkaloids (e.g., berberine (https://www.foundmyfitness.com/topics/berberine)), organosulfur compounds (e.g., sulforaphane), and terpenoids (e.g., beta carotene). A growing body of evidence suggests that polyphenols have disease-fighting properties, although the evidence to support these claims varies in quality. Research has demonstrated some degree of efficacy ... polyphenol brain cancer heart disease green tea gut diet microbiome microbes
Read moreHeart disease, including atheroslcerotic cardiovascular disease, is a leading cause of death worldwide. Its associated inflammation and metabolic dysfunction can be prevented with a diet high in nutrient dense foods such as those commonly found in the Mediterranean diet (https://www.mdpi.com/1422-0067/20/19/4716). Findings of a new report indicate that a high intake of vitamin K - a micronutrient found at high levels in common Mediterranean meals - might reduce the incidence of atherosclerotic disease. Atherosclerosis refers to the hardening of arteries due to the formation of plaques composed... heart disease vitamin k
Read more[toc position='left'] Background Collagens are major structural proteins in numerous body tissues, including tendons, ligaments, cartilage, skin, blood vessels, muscles, gut tissue, and dentin.[ref doi='10.1101/cshperspect.a004978'] They are the most abundant proteins in the body, comprising 30 percent of the total protein mass. The human body continuously manufactures collagens to maintain tissue structural integrity. However, aging drives a progressive decrease in protein synthesis and reduced capacity to produce new collagen.[ref doi='10.1016/S0047-6374(01)00337-2'] Collagens are also highl... interesting nutrition aging metabolism autoimmunity
Read more[toc position='left'] Creatine is a naturally occurring compound that is critical in storing and releasing cellular energy. It also participates in many biological processes driving pregnancy outcomes, maintaining bone mineral density and muscle mass in older adults, improving neurological function, and aiding the immune system to fight cancer. Creatine is best known for its widespread use as a dietary supplement to enhance physical performance. Creatine uptake, synthesis, storage, and supplementation Creatine uptake Creatine can be supplied exogenously (from dietary or supplemental sources) ... metabolism neurodegeneration nutrition brain aging depression pregnancy
Read more[toc position='left'] Salmon roe – sometimes referred to as "salmon caviar" – is the internal egg mass found in female salmon. It is served in a variety of dishes, including sushi and pasta, or as a garnish or condiment to seafood or eggs. Salmon roe is rich in protein, vitamins, astaxanthin, and the omega-3 fatty acids eicosapentaenoic acid, or EPA, and docosahexaenoic acid, or DHA. Omega-3 fatty acids are long-chain polyunsaturated fatty acids. They are considered essential fatty acids because the human body cannot make them. Alpha-linolenic acid, or ALA, an omega-3 fatty acid that serves a... brain aging omega-3 diet mental health dementia alzheimer's
Read moreDr. Eric M. Verdin discusses the roles of the ketogenic diet, beta-hydroxybutyrate, HDAC inhibitors, NAD+, and more in the context of aging. ... aging nutrition ketosis fasting mitochondria video ketogenic diet
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