Tau is a protein abundant in nerve cells, and its abnormal forms are linked to brain deterioration in Alzheimer's disease and other neurological conditions. Researchers investigated how tau affects mitochondria, the cell's energy-producing structures, and whether interrupting that interaction could protect neurons. The study combined animal models, human neurons grown from stem cells, and brain tissue collected after death from people with and without tau-related disorders, including Alzheimer's disease. In animal and cell experiments, researchers altered tau and examined whether reverse elect... alzheimer's dementia mitochondria neurodegeneration neurons
Read moreIn this solo episode, I'm taking an in-depth look at magnesium – a critical yet frequently underestimated mineral in our health. ... magnesium brain cancer aging dna damage
Watch nowIn my keynote at LongevityFest 2023, I share powerful habits to delay aging and improve healthspan, presented at the American Academy of Anti-Aging Medicine. ... aging vitamin d exercise omega-3 micronutrients magnesium bdnf
Watch nowVery low-calorie diets elicit extensive changes to the gut microbiota, influencing weight loss. Many popular diet programs emphasize calorie reduction as a means to lose weight. However, this approach to weight loss minimizes evidence suggesting that the gut microbiota plays important roles in body weight and likely influences the host's metabolic response to diet. Findings from a recent study suggest that very low-calorie diets elicit extensive changes to the gut microbiota, influencing how much weight a person loses when dieting. Low-calorie diets (1,200 to 1,500 calories per day) and very ... diet obesity microbiome
Read more...m endothelial dysfunction, BBB break-down, and inflammation.[ref doi='10.3390/ijms22094958'] Alzheimer's disease [tweetbox slug="small-vessel-disease-dimentia"] Alzheimer's disease is a type of dementia that presents with plaques of misfolded amyloid-beta and phosphorylated tau proteins in the brain.... small vessel disease brain alzheimer's vitamin d omega-3 parkinson's inflammation cardiovascular blood-brain barrier
Read moreDr. Peter Diamandis and Tony Robbins discuss the application of precision medicine and health technologies in slowing human aging. ... aging cancer epigenetics performance immune system crispr
Watch nowAging involves a progressive decline in the body’s ability to heal from damage (a property known as resilience) and a gradual increase in the risk of age-related diseases like cancers, diabetes, and cardiovascular diseases. Aging research aims to increase lifespan and healthspan through pharmacological and lifestyle interventions that enhance cellular repair and reduce exposure to harmful substances. Findings of a recent report propose a possible maximum age for humans. As the field of aging research grows, several aging "clocks" have been proposed as ways to measure biological age. These cloc... aging
Read moreCancer is the second leading cause of death following cardiovascular disease. For many cancers, the risk may be reduced by consumption of a healthy diet rich in plant-based foods because many plants contain anticancer compounds. One team of researchers aimed to determine the role of mushroom consumption in reducing cancer risk. Mushrooms are rich in bioactive compounds, including phytochemicals (plant chemicals such as flavonoids and carotenoids), fiber, selenium, vitamins, and antioxidants, such as ergothioneine and glutathione, which may help prevent cancer. While laboratory studies have sho... cancer mushroom
Read moreObesity and metabolic disease are associated with reduced fertility and alterations in several markers of reproductive health, including plasma concentrations of sex hormone-binding globulin. Low levels of sex hormone-binding globulin are common in those with obesity and are predictive of cardiovascular disease and type 2 diabetes risk, although it is unclear how glucose and insulin regulation affect sex hormone-binding globulin levels. A group of investigators recently performed a series of experiments with the aim of identifying mechanisms of sugar metabolism and sex hormone-binding globulin... testosterone estrogen sugar
Read more[toc position='left'] Bathing oneself in heat for the purposes of purification, cleansing, and healing is an ancient practice, dating back thousands of years and observed across many cultures. Variations of its use are seen today in the banyas of Russia, the sweat lodges of the American Indians, and, most famously, the saunas of Finland. Sauna use, sometimes referred to as "sauna bathing," is characterized by short-term passive exposure to extreme heat. This exposure elicits mild hyperthermia – an increase in the body's core temperature – that induces a thermoregulatory response involving neu... exercise inflammation sauna aging performance depression bisphenol a heat stress interesting alzheimer's
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