Alzheimer's disease affects more than 24 million people worldwide, with numbers expected to grow as the population ages. A growing body of evidence links mitochondrial dysfunction and oxidative stress to the development of Alzheimer's disease. A recent study in mice found that sulforaphane, a bioactive compound derived from broccoli and broccoli sprouts, boosts memory, improves mitochondrial function, and reduces oxidative stress. Researchers studied normal mice and mice prone to developing a condition similar to Alzheimer's. They fed half of each type of mice standard mouse chow. They fed th... brain alzheimer's mitochondria dementia sulforaphane oxidative stress
Read moreHyperglycemia, which occurs when glucose levels in the blood rise to dangerous levels, is a hallmark of diseases such as metabolic syndrome and type 2 diabetes. The effects of hyperglycemia are well documented and include cellular damage, inflammation, and pro-cancer effects (https://pubmed.ncbi.nlm.nih.gov/27931833/); however, few studies have elucidated the cellular mechanisms of hyperglycemia. Findings of a new report suggest mitochondrial damage explains the connection between hyperglycemia and disease. Glucose is consumed in the diet from simple sugars and starches. Glucose transport pro... sugar ketogenic diet
Read moreStress is essential to human survival. Long-term exposure to stress, however, increases a person's risk of developing many chronic diseases. A recent review suggests that sauna bathing protects the body from the harmful effects of high stress occupations and describes the mechanisms that drive the protection. People who work in high-stress occupations, such as firefighters, first responders, and military members, are exposed to both physiological and psychological stressors – often referred to as dual stressors. These dual stressors activate physiological responses to stress that ultimately ... stress sauna
Read moreLoss of olfactory system function – the sense of smell – is an early indicator of cognitive decline in people with type 2 diabetes and obesity. A new study in mice demonstrates the negative effects of a high-fat, high-sugar Western dietary pattern on odor-related learning and memory. Smell is an important regulator of behavior and memory, especially in non-human animals like mice. Olfactory system dysfunction may be due to decreased neurogenesis in the olfactory regions of the brains. In this way, changes in smell may signal decreased neurogenesis in other areas of the brain, which may indica... obesity diet memory fat nose sugar
Read moreDNA damage at telomeres drives senescence in cardiac cells. Removing senescent cardiac muscle cells from the hearts of aged mice, both genetically and using drugs, reduces hypertrophy and fibrosis in aged hearts and restores cardiac health. To learn more about what cellular senescence is, what causes it, and how to prevent it check out the podcast with the expert Dr. Judy Campisi. Episode: https://www.foundmyfitness.com/episodes/judy-campisi ... aging heart disease telomeres dna damage
Read moreClearing away senescent cells in the brain using senolytic drugs prevented brain degeneration in mice genetically prone to it. The diseased animals were able to form memories, eliminated signs of inflammation, and did not develop tangles in the brain. I have a great episode with an expert on cellular senescence. I recommend checking out the recently revamped show notes even if you don’t have the time for the full episode. https://www.foundmyfitness.com/episodes/judy-campisi ... alzheimer's aging
Read moreSome of the mechanisms by which exercise protects against cancer and sensitizes cancer cells to death include: •Increased blood flow, shear stress on the vascular bed, temperature increases, sympathetic activation and endocrine (release of catecholamines and exercise hormones, myokine secretion) •Increased tumor perfusion, oxygen delivery, •Metabolic stress within the tumor, cellular damage, and reactive oxygen species production. These acute changes are able to elicit signaling pathways that prevent metastasis. •Improved immune function, reduced systemic inflammation, and improved meta... exercise cancer
Read moreDr. Rhonda Patrick explains cold shock as hormesis, a beneficial stressor that triggers adaptive processes, promoting resilience. ... cold stress exercise brain cancer obesity performance inflammation immune system mental health muscle
Listen nowFTA: > Calorie restriction during treatment for breast cancer changes cellular programming in a way that lowers the chance of metastases in mice. Breast cancer patients are often treated with hormonal therapy to block tumor growth, and steroids to counteract the side effects of chemotherapy. However, both treatments can cause a patient to have altered metabolism which can lead to weight gain. In fact, women gain an average of 10 pounds in their first year of treatment. Recent studies have shown that too much weight makes standard treatments for breast cancer less effective, and those who ga... cancer fasting weight loss
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