Dr. Rhonda Patrick and Dr. Steve Horvath discuss how epigenetic clocks measure biological age and which proven interventions actually slow or reverse aging. ... epigenetics telomeres genetics stem cells omega-3 dna damage biomarkers aging vitamin d senescence multivitamin
Watch nowDr. Rhonda Patrick discusses coffee's remarkable ability to slow biological aging, reduce DNA damage, and lower cancer risk. ... coffee alzheimer's caffeine dementia brain diet cholesterol L-Theanine
Watch nowDr. Rhonda Patrick describes strategies you can apply immediately to enhance your health and prevent chronic disease. ... rhonda nutrition exercise brain cancer aging metabolism omega-3 micronutrients cardiovascular
Watch nowExercise puts a demand on skeletal muscle cells to produce energy at a faster rate than at rest. To do this, the body increases the delivery of fats to the muscle mitochondria while increasing the mitochondrial capacity to metabolize fats, a process called beta-oxidation. Researchers of a new study aimed to illuminate the cellular mechanisms of mitochondrial fat metabolism following moderate intensity aerobic exercise. Mitochondria are cellular structures responsible for the production of energy in the form of adenosine triphosphate (ATP). The inner membrane of mitochondria possess a series of... exercise fat
Read moreNrf2 (nuclear factor erythroid 2-related factor 2) is a cellular protein that regulates the expression of antioxidant and stress response proteins. It participates in the Keap1/Nrf2/ARE biological pathway – the primary mechanism by which sulforaphane exerts its beneficial effects. A 2017 review describes the role of sulforaphane in the Keap1/Nrf2/ARE pathway and summarizes the beneficial health effects associated with the compound. The Keap1/Nrf2/ARE pathway is a key mediator of cytoprotective responses to oxidative and electrophilic stressors. Under normal cellular conditions, Keap1 tethers ... nutrition sulforaphane glutathione nrf2
Read moreAlzheimer’s disease is a neurodegenerative disorder characterized by progressive memory loss, cognitive decline, and behavioral changes. Roughly 50 million people have Alzheimer's disease worldwide (https://www.who.int/news-room/fact-sheets/detail/dementia). Researchers have developed a blood test that measures phospho-tau217 (p-tau217), a type of tau protein, and may be useful in diagnosing Alzheimer's disease as early as 20 years before symptoms manifest. Tau is a protein that clumps together and forms tangles inside neurons in the brains of people with Alzheimer's disease. When tau tangles... alzheimer's
Read moreTransplanting senescent cells into young mice caused physical dysfunction and decreased lifespan when transplanted into old mice. On the other hand, selective clearance of senescent cells increased lifespan by 36% and improved physical function in old age. Drugs that selectively target senescent cells are referred to as senolytics. This study also showed that senolytics killed human senescent cells in human fat samples. To learn more about what causes cellular senescence, how it accelerates aging and plays a role in age-related diseases, and possible ways to prevent it...check out my podcast w... aging
Read moreFTA: > Having coronary artery disease increased the men's risk of prostate cancer by 35 percent, with the risk rising over time. The group was 24 percent more likely to be diagnosed with prostate cancer within the first two years of the study than men who reported no heart disease, and by four years into the study, this group's prostate cancer risk was 74 percent higher. *That's a pretty close relationship! *While this study didn't seem to outline the underlying mechanism connecting the diseases, we know one likely candidate that's participating in both diseases: inflammation. Inflammation... cancer heart disease prostate
Read moreAn antioxidant compound that is used in dye and has shown promise in treating Alzheimer's disease has now shown potential in reversing skin aging in human skin. The compound is called methylene blue and is a very potent antioxidant. It was able to repair damaged skin cells, lower the rate of cell death, increase the rate of cell division, reduce reactive oxygen species, and reduce markers of cellular senescence in skin from both middle-aged donors and elderly. Methylene blue was also tested on artificial skin, which reacts like regular skin, and found that it retained more water and increased ... aging skin antioxidant
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