Dr. Rhonda Patrick and Dr. Steve Horvath discuss how epigenetic clocks measure biological age and which proven interventions actually slow or reverse aging. ... epigenetics telomeres genetics stem cells omega-3 dna damage biomarkers aging vitamin d senescence multivitamin
Watch nowSauna studies often focus on long-term health patterns, but the immediate changes that occur in the body during heat exposure are less clear. In a new study, researchers tested how one traditional Finnish sauna session affected the immune system. The study included 51 middle-aged adults in Finland who had at least one cardiovascular risk factor (e.g., high blood pressure or diabetes) but no known cardiovascular disease. Each participant completed a 30-minute dry sauna session at about 73°C (163.4°F) with 10 to 20% relative humidity, including a short 2-minute shower after the first 15 minutes... immune system sauna
Read moreCollagen supplements are widely promoted for improving skin, joint health, and physical performance, yet the scientific evidence behind these claims often remains inconsistent and unclear. To clarify which claims are actually supported by scientific evidence, researchers conducted an umbrella review, a study that combines results from many previous systematic reviews and clinical trials into a single analysis. The researchers examined 16 meta-analyses covering 113 randomized controlled trials with 7,983 participants. In these studies, people took different forms of collagen supplements and we... muscle skin supplements
Read moreInflammation during pregnancy can increase the risk of complications for both mother and baby. Researchers in Canada explored whether an often underconsumed nutrient, choline, might be linked to lower levels of inflammation late in pregnancy. The study drew on data from 1,300 participants in the Alberta Pregnancy Outcomes and Nutrition cohort. At about 32.5 weeks of pregnancy, each participant completed a detailed 24-hour dietary recall and provided a nonfasting blood sample. Researchers measured high-sensitivity C-reactive protein (hs-CRP, a sensitive blood marker of inflammation), choline i... choline inflammation pregnancy
Read moreNon-alcoholic fatty liver disease (NAFLD), now usually termed metabolic dysfunction-associated steatotic liver disease (MASLD), affects about one in four people worldwide and can progress to serious liver injury and even liver cancer. Because there are only limited pharmacologic options to prevent its progression, researchers are also looking closely at diet and supplements as possible tools. A new large study examined whether people who regularly take fish oil supplements face a lower risk of developing severe forms of this disease. Using data from the UK Biobank, investigators followed 488,... fatty liver omega-3
Read moreDepression and anxiety are leading causes of disability, yet standard treatments rarely address the metabolic disturbances that often accompany these conditions. Ketogenic diets have been suggested as one way to target this problem. In a systematic review and meta-analysis, researchers looked at 50 human studies including 41,718 adults from psychiatric and nonpsychiatric settings in 15 countries. Interventions were ketogenic-style diets high in fat, moderate in protein, and limited to no more than 25% of calories from carbohydrate or under 50 grams per day, compared with control diets in rand... anxiety depression ketogenic diet ketosis mental health
Read moreThe glymphatic system—the brain's waste clearance network—uses cerebrospinal fluid to flush out toxic metabolic byproducts, including amyloid-beta, tau, and other protein aggregates. This clearance process plays a critical role in maintaining brain health and may help protect against neurodegenerative diseases, such as Alzheimer's. A recent study in mice found that a network of lymphatic vessels in the neck aids glymphatic waste removal, and this system can be enhanced using a gentle, non-invasive technique. Researchers viewed the lymphatic vessel function of mice using fluorescent tracers. Th... aging brain
Read moreThe brain needs a steady supply of energy to function correctly, and this energy supply often breaks down in the early stages of Alzheimer's disease. Some evidence suggests that problems with the brain's creatine system may play a role in this decline. A recent study found that creatine supplements improved brain energy use, reduced the buildup of Alzheimer's disease-related proteins, and boosted memory in mice. Researchers conducted an eight-week pilot study involving 20 people with cognitive impairment due to Alzheimer's disease. All participants took 20 grams of creatine monohydrate daily a... alzheimer's brain
Read moreZinc is an essential nutrient that participates in many biological processes, modulating the activity of more than 300 enzymes and 2,000 transcription factors. It plays critical roles in immune function, protein synthesis, wound healing, DNA synthesis, and cell division. A recent study found that moderate zinc intake reduces the risk of hypertension; however, higher intakes markedly increase the risk. The study involved more than 12,000 participants who did not have hypertension at their enrollment. Researchers assessed the participants' dietary intake using three consecutive 24-hour dietary ... nutrition zinc blood pressure
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