Calorie restriction does more than reduce body fat; it also changes how cells maintain and repair themselves. Researchers investigated whether semaglutide, a GLP-1 receptor agonist widely used for weight loss, could reproduce some of those effects when given late in life. The experiments began in female mice at 20 months of age. One randomized comparison followed 40 mice receiving daily semaglutide and 39 receiving inactive saline injections until their death. Separate mice underwent three months of treatment before tests of memory, physical abilities and glucose control, alongside cellular s... cognition diabetes exercise GLP-1 inflammation neurodegeneration neurogenesis neurons weight loss
Read moreDr. Rhonda Patrick examines how one cup of blueberries daily may support vascular function, cognitive aging, metabolic health, and the gut microbiome. ... nutrition exercise brain gut aging microbiome insulin resistance inflammation memory rhonda polyphenol cardiovascular
Watch nowCardiovascular disease is the leading cause of death in the United States, but men and women do not develop it on the same timeline. To identify when these differences begin, researchers followed a large group of adults from young adulthood into midlife and recorded when their first cardiovascular events occurred. The analysis used data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, which enrolled 5,115 adults aged 18 to 30 in the mid-1980s and followed them for more than 30 years. Researchers compared men and women to determine when "premature" cardiovascular disea... aging cardiovascular
Read moreStatins are the first line of defense against high LDL cholesterol, but increasing the dose for better results often leads to more side effects. A team of researchers wanted to know whether adding a simple fiber supplement could make a standard statin dose more effective. To find out, they analyzed data from three clinical trials that tested psyllium taken with a statin versus the same statin taken alone. The studies included 204 adults, mostly with high LDL cholesterol, who received treatment for 4 to 12 weeks. Statins used included simvastatin, atorvastatin, or lovastatin, at doses of 10 to ... cholesterol fiber
Read moreFrom the article: Researchers have confirmed three gene changes that raise the risk that a blood vessel in the brain will weaken and balloon out (aneurysm), creating a life-threatening chance of rupture. Smoking, the biggest risk factor for brain aneurysm, is five times more dangerous in people with these gene variations. However, a second study on the same population notes that most people with aneurysm die of cancer or heart problems. [...] In one study (Broderick, abstract 156), researchers found that the chance of an intracranial aneurysm increased between 37 percent and 48 percent for ... genetics tobacco aneurysm
Read moreEating twice a day, without restricting calories, may prevent metabolic syndrome. Metabolic syndrome is a constellation of medical conditions that includes high blood pressure, high blood glucose, unhealthy cholesterol levels, and excess abdominal fat. Having metabolic syndrome increases a person's risk of heart disease, stroke, and diabetes. Findings from a 2017 study suggest that eating two meals per day, without caloric restriction, induces inter-meal autophagy, potentially preventing metabolic syndrome. Calorie restriction is the practice of long-term reduced dietary intake, typically c... fasting autophagy
Read moreAround 93% of the people receiving the intravenous vitamin C are responding to chemotherapy and radiation, compared to 40% who usually do. The intravenous vitamin C may also show encouraging results in a small sample of people with glioblastoma. Remember that oral doses of vitamin C (even liposomal) can not achieve the same plasma concentrations that IVC can, which are between 800 to 1,000-fold higher. Other studies have revealed mechanisms by which the IVC works including the production of hydrogen peroxide which selectively kills cancer cells. Normal cells can detoxify the hydrogen peroxide ... cancer vitamin c vitamin a
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