AI-designed drugs could open a new path toward treatments that slow or reverse aspects of human aging. Researchers investigated whether rentosertib, developed to treat idiopathic pulmonary fibrosis (a lung-scarring disease), could also affect age-related biological changes. Researchers analyzed blood samples from 42 adults with an average age of 67 and idiopathic pulmonary fibrosis who completed a randomized, double-blind trial. Participants received rentosertib at 30 mg once daily, 30 mg twice daily, or 60 mg once daily, or placebo, for 12 weeks alongside usual treatment. Six "aging clocks" c... aging drug
Read moreWhen people struggle with major goals, such as finishing a degree or pursuing a career path, they often reach a moment of deep uncertainty about whether to continue. A new study asked whether the critical ingredient in these moments is not doubt itself, but the degree of trust people place in their doubts. The researchers ran two experiments, each focused on a personally important long-term goal. First, all participants completed a short questionnaire measuring how conflicted they felt about their goal, a state psychologists call an action crisis, meaning they were weighing whether to persist... behavior
Read more[toc position='left'] Introduction [tweetbox text='"The beneficial effects of cold exposure may be due to hormesis, a favorable biological response to a mild stressor."' tweet='"The beneficial effects of cold exposure may be due to hormesis, a favorable biological response to a mild stressor." https://www.foundmyfitness.com/topics/cold-exposure-therapy'] Cold exposure to promote good health is an ancient practice, now used to reduce muscle soreness and promote muscle recovery after physical activity. However, regular cold exposure may also improve glucose and lipid metabolism, decrease inflamm... performance cholesterol immune system thermogenesis cold stress brain heart disease diabetes insulin resistance inflammation depression mitochondria neuron blood pressure interesting
Read moreHuntington’s disease is a progressive neurodegenerative disorder characterized by uncontrolled movements, speech problems, personality changes, and dementia. The disease is caused by a single genetic mutation, called a CAG repeat, that drives abnormal protein folding and aggregation of the huntingtin protein and subsequent death of striatal neurons. Findings from a 2010 study demonstrate that modulating pathways involved in BDNF-mediated signaling shows promise as a therapeutic against Huntington's disease. Evidence suggests that normal huntingtin promotes the expression of BDNF, but mutated ... brain bdnf neurodegeneration
Read more[toc position='left'] Nutrition in the first year of life is crucial to an infant's development and lifelong health. Early nutritional deficits are intrinsically linked to impaired mental and physical growth. Consequently, the risk of developing metabolic and cardiovascular diseases such as obesity, diabetes, and hypertension in childhood and later life is likely determined by early feeding and nutritional status. Breastfeeding is the biologically superior way to feed an infant. The American Academy of Pediatrics recommends exclusive breastfeeding for the first six months of an infant's life ... cancer breast cancer circadian rhythm nutrition brain microbiome heart disease diabetes inflammation alcohol stem cells immune system development intelligence
Read moreObesity is associated with a plethora of problems, but it is also associated with severe micronutrient deficiencies, including vitamin D. A paper I published in 2014 explains a mechanism by which vitamin D affects serotonin and makes a case for how this might be able to affect autism since normal fetal brain development requires serotonin. Here is the link to press release on my study: http://www.sciencedaily.com/releases/2014/…/140226110836.htm ... vitamin d nutrition brain obesity micronutrients vitamin a
Read more> In response to T. gondii, the body produces natural killer cells and cytotoxic T cells. These cell types wage war against cancer cells. Cancer can shut down the body's defensive mechanisms, but introducing T. gondii into a tumor environment can jump start the immune system. > "The biology of this organism is inherently different from other microbe-based immunotherapeutic strategies that typically just tickle immune cells from the outside," said Barbara Fox, senior research associate of Microbiology and Immunology. "By gaining preferential access to the inside of powerful innate immune ... cancer immune system
Read morenutrition fulltext ketosis schizophrenia gluten carbohydrates ketogenic diet
Read more