Dr. Derya Unutmaz joins Dr. Rhonda Patrick to discuss how AI could extend lifespan, personalize cancer care, and transform medicine within a decade. ... technology genetic engineering diagnostics aging stem cells immune system cancer epigenetics brain
Watch nowVitamin D plays a crucial role in the early development of dopamine-producing neurons, shedding light on the potential neurodevelopmental origins of schizophrenia. Abnormalities in dopamine signaling are at the heart of this complex mental health disorder, and a recent study suggests that vitamin D deficiency during pregnancy influences these pathways, increasing the risk of schizophrenia in offspring. Researchers examined nerve growth, synapse formation, and dopamine release in various dopamine-producing cells exposed to vitamin D over time. They focused on SH-SY5Y cells—which can mature into... vitamin d brain pregnancy micronutrients mental health development schizophrenia dopamine
Read moreDr. Peter Diamandis and Tony Robbins discuss the application of precision medicine and health technologies in slowing human aging. ... aging cancer epigenetics performance immune system crispr
Watch nowSulforaphane is a bioactive compound derived from certain cruciferous vegetables, such as broccoli and broccoli sprouts. It exerts potent anti-inflammatory properties and switches on the activity of a vast array of cellular protective proteins. A new study in mice demonstrates that sulforaphane inhibits activation of the NLRP3 inflammasome in mice microglia cells via inhibition of the NF-kB pathway and altered gene expression. Inflammasomes are large, intracellular complexes that detect and respond to internal and external threats. Activation of inflammasomes has been implicated in a host of ... inflammation sulforaphane nrf2 nlrp3
Read moreβ-hydroxybutyrate production consequent to exercise induces within the muscle the activities of a key promoter involved in the production of brain-derived neurotrophic factor. From the article: > Studies have shown that BDNF levels in the brains of people with Alzheimer's or Huntington's disease are, on average, half that of people without either brain-damaging disease. > Among the key findings of the current study was that a ketone, a chemical naturally produced in the liver called beta-hydroxybutyrate (DBHB), triggers biological reactions that activate the BDNF gene to produce more of... exercise brain alzheimer's diet ketosis bdnf hdac inhibitor
Read moreAs we age, our ability to learn things and form new memories decreases. Navigation, which incorporates multiple cognitive processes including memory, attention, and our perception of direction and distance, becomes particularly difficult with aging. Findings from a recent study suggest that increasing adult neurogenesis may improve navigation capacity in older mice. Neurogenesis is the process of forming new neurons. It is essential during embryonic development, but also continues in certain brain regions throughout human lifespan to facilitate learning and memory formation. The study author... neurons protein
Read moreMaintaining a healthy weight requires balancing energy intake with expenditure. A variety of elements influence how physically active we are, including genetic, cultural, and environmental factors. Evidence from a new study suggests that epigenetic changes in agouti-related proteins may regulate voluntary exercise behavior in mice. Agouti-related proteins are neuropeptides produced primarily in the hypothalamus. They regulate appetite, metabolism, and energy expenditure. Epigenetic changes are biological mechanisms that regulate gene expression (how and when certain genes are turned on or of... exercise epigenetics protein
Read moreFOXO proteins are members of the FOX family of highly conserved transcriptional regulators. They play essential roles in human lifespan and healthy aging, influenced by environmental and genetic factors. The genetic contribution to lifespan and aging increases with time, suggesting that people who live long lives might carry so-called "protective genes." Run the longevity report to learn more about genetic polymorphisms influencing the expression of FOXO (/genetics) Background FOX proteins are named for a gene found in fruit flies that causes the insects to have forked structures on their head... aging fasting nutrition diet
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