Long periods of sitting are linked to poorer metabolic and cardiovascular health, yet many people struggle to fit structured exercise into busy days. A new pilot study tested whether exercise snacks, brief structured activity bouts, could improve fitness and cardiometabolic markers in sedentary women. Twenty-two healthy women aged 18 to 45 took part in the study, including 11 sedentary women and 11 physically active women who served as a reference group. Only the sedentary women completed a supervised daily exercise circuit for eight weeks, with each session lasting less than 12 minutes and c... autophagy cardiovascular exercise exercise snacks heart disease immune system insulin insulin resistance metabolism mitochondria muscle
Read moreDr. Rhonda Patrick and Dr. Charles Brenner discuss NAD precursors, NR versus NMN, NAD IV drips, and what truly boosts NAD for recovery and longevity. ... nad+ pregnancy dna damage aging resveratrol oxidative stress
Watch nowCompounds derived from cruciferous vegetables may influence not only disease prevention but also the fundamental processes of aging. A recent roundworm study found that sulforaphane, a bioactive compound derived from broccoli, extended lifespan by more than 50%, but only when taken early in life. Scientists administered varying doses of sulforaphane to roundworms (a robust aging model) throughout different stages of their lives. They also monitored changes in gene activity over time to create an "aging clock" based on transcription patterns—essentially a readout of the worms' biological age de... aging diet
Read moreMany factors influence human emotions and behavior. A key player in their regulation is the gut microbiome – the community of microbes that resides in the intestinal tract. Findings from a new study show indicate that antibiotic use early in life alters neuropeptide signaling pathways that influence behavioral development. Antibiotics are often prescribed to treat ear infections, respiratory illness, and diarrhea in children. They are among the most commonly prescribed drugs among children living in the United States (https://pediatrics.aappublications.org/content/130/1/23.short). Neuropept... microbiome
Read moreEarly life environmental exposures play key roles in our ability to launch an effective immune response due to a phenomenon referred to as "immunological imprinting" – the process by which the immune system fights infections after previous exposure to a pathogen. A commonly held theory was that previous exposure to an influenza virus conferred no immunological protection against subsequent exposure. However, new data suggest that immunological imprinting due to exposure to subtypes of influenza viruses during childhood may provide partial lifelong protection against other subtypes. Influenza i... immune system virus
Read moreFasting and other forms of caloric restriction are associated with reduced risk of many chronic diseases. Monocytes, white blood cells that play key roles in the body's immune response, can contribute to the pathogenesis of chronic inflammatory diseases. Findings from a new study demonstrate that fasting reduces the number of circulating monocytes without compromising immune function. The authors of the study analyzed blood samples from 12 healthy adults taken at the beginning of the study (baseline), three hours after they ate, and 19 hours after commencing a fast. All the samples were taken... fasting time-restricted eating
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