AI-designed drugs could open a new path toward treatments that slow or reverse aspects of human aging. Researchers investigated whether rentosertib, developed to treat idiopathic pulmonary fibrosis (a lung-scarring disease), could also affect age-related biological changes. Researchers analyzed blood samples from 42 adults with an average age of 67 and idiopathic pulmonary fibrosis who completed a randomized, double-blind trial. Participants received rentosertib at 30 mg once daily, 30 mg twice daily, or 60 mg once daily, or placebo, for 12 weeks alongside usual treatment. Six "aging clocks" c... aging drug
Read moreTNF-alpha in the brain drives sickness behaviors associated with liver disease. Many liver disorders cause behavioral symptoms, often referred to as sickness behaviors, such as fatigue, loss of appetite, and "brain fog." Evidence suggests that these symptoms arise from alterations in the central nervous system (https://pubmed.ncbi.nlm.nih.gov/11592605/), but scientists don't fully understand what drives them. Findings from a 2006 study suggest that sickness behaviors in the setting of cholestasis, a common liver disorder, are caused by the presence of tumor necrosis factor-alpha (TNF-alpha), a... brain inflammation behavior tnf-alpha
Read moreRoutine hyperbaric treatment increased telomere length and reduced senescence in humans. With age, tissues lose their ability to function properly, leading to an increased risk of cancer, cardiovascular disease, and Alzheimer's disease, among others. Cells become exhausted from replication over time and enter a state of senescence, meaning they will no longer reproduce because they are damaged. Findings of a new report demonstrate the ability of hyperbaric treatments to reduce the number of senescent immune cells. Hyperbaric (i.e., high air pressure) treatments use increased atmospheric pressu... aging telomeres
Read moreCurcumin is the principal bioactive compound present in the yellow spice turmeric. An abundance of scientific evidence indicates that curcumin has antioxidant, anti-inflammatory, anticancer, and neuroprotective properties (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/) in humans. Findings from a 2019 study suggest that curcumin improves exercise tolerance in mice with heart failure via its activation of Nrf2. Heart failure, commonly referred to as the end stage of heart disease, affects more than 26 million people worldwide (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494150/). Exer... exercise heart disease curcumin antioxidant nrf2
Read moreCurcumin is the principal bioactive compound present in the yellow spice, turmerice. An abundance of scientific evidence indicates that curcumin exerts antioxidant, anti-inflammatory, anticancer, and neuroprotective properties (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/) in humans. Findings from a 2019 study suggest that curcumin improves exercise tolerance in mice with heart failure via its activation of Nrf2. Heart failure, commonly referred to as the end stage of heart disease, affects more than 26 million people worldwide (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494150/).... exercise heart disease curcumin nrf2
Read moreMost pregnant women who develop COVID-19 experience mild or asymptomatic illness and rarely transmit the disease to their infants in utero or postpartum. Findings from a new study suggest that specialized "decoy" proteins in amniotic fluid and breast milk protect fetuses and newborns from severe COVID-19. SARS-CoV-2, the virus that causes COVID-19, gains entry to cells via various receptor proteins, including angiotensin-converting enzyme 2 (ACE2), CD26, CD147, and neuropilin-1 (NRP-1), among others. These proteins are typically embedded in cellular membranes, but they can also be found in so... covid-19 breast milk
Read moreSARS-CoV-2, the virus that causes COVID-19, binds to a receptor on a cellular receptor called angiotensin-converting enzyme 2 (ACE2) to enter the cell and replicate. This process markedly impairs ACE2 receptor function (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167588/). Findings from a recent study suggest that antibodies for the ACE2 receptor develop after COVID-19 illness, driving long-term complications. Most people recover from COVID-19 illness within a few weeks of symptom onset. Some, however, experience long-term complications that last several weeks or months, a phenomenon previo... covid-19
Read moreCognitive decline is a personally challenging issue that degrades the quality of life for those affected. It is also a growing public health burden, with one in nine adults aged 65 years and older living with some level of cognitive impairment. Previous research has identified dietary components that reduce age-related cognitive impairment (http://www.jpreventionalzheimer.com/all-issues.html?article=99), including vitamin E, folate, and vitamin D. Authors of a new report investigated the effects of creatine on cognitive function in older adults. Creatine is a compound found primarily in the br... brain aging
Read moreEmotional stressors can become overwhelming, potentially setting in motion a cascade of hormonal and physiological responses that are deleterious to a person's mental and physical health. Evidence suggests that prolonged exposure to emotional stressors increases a person's risk of developing cardiovascular disease, metabolic dysfunction, and depression. Findings from a recent study demonstrate that Ashwagandha root extract enhances a person's capacity to handle stress. Commonly referred to as winter cherry, Indian ginseng, or poison gooseberry, Ashwagandha is an herbaceous plant from the Sola... anxiety stress cortisol supplements
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