People who exercise regularly can still spend most of their day sedentary. A new study examined whether the cardiovascular benefits of exercise training also extend to maintaining artery function during prolonged sitting. Eleven young, healthy adults completed 12 weeks of supervised high-intensity interval cycling three times weekly, while 10 adults maintained their usual activity and served as a control group. Before and after the program, ultrasound tests assessed the popliteal artery behind the knee before and after approximately two hours of uninterrupted sitting. One test measured artery... cardiovascular exercise oxidative stress
Read moreDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session. ... rhonda brain cancer microbiome sleep omega-3 fasting circadian rhythm vaccine skin
Watch now[toc position='left'] A single layer of epithelial cells lines the entire digestive tract, facilitating the exchange of nutrients between the intestine and the bloodstream. This layer, referred to as the intestinal epithelium, must be permeable to nutrients yet impermeable to pathogens. [tweetbox text='"Increased intestinal permeability (also known as "leaky gut") allows pathogens to leak through the intestinal barrier and pass directly into the bloodstream, promoting inflammation."' tweet='"Increased intestinal permeability (also known as "leaky gut") allows pathogens to leak through the int... intestinal permeability butyrate gut microbiome polyphenol autoimmunity
Read moreSleep is essential for maintaining optimal physical health. Evidence suggests that adults who don't get enough sleep have a greater risk of developing many chronic diseases (https://academic.oup.com/biomedgerontology/article/74/2/204/4837199?login=true) and tend to overeat (https://www.nature.com/articles/ejcn2016201?cookies=accepted). Findings from a recent study suggest that teens consume more sugar when they don't get enough sleep. Sleep patterns change markedly during the adolescent years, driven by shifts in circadian rhythms and subsequent sleep latency (https://onlinelibrary.wiley.com/d... sleep sugar
Read moreIn recent years, vaping, or smoking electronic cigarettes (e-cigarettes), has emerged as a popular substitute for smoking tobacco-containing cigarettes. E-cigarettes produce a vapor that may contain nicotine as well as a variety of toxic substances, including some carcinogens. Findings from a new study suggest that some compounds in e-cigarettes trigger inflammation, promoting a leaky gut. Leaky gut, otherwise known as intestinal permeability, is a condition in which gaps form between the tight junctions between the endothelial cells that line the gut. These gaps allow pathogens like bacteria... gut intestinal permeability lipopolysaccharide
Read moreThe primary cause of death from COVID-19 is acute respiratory distress syndrome (ARDS), a severe form of acute lung injury characterized by rapid breathing, shortness of breath, and a low blood oxygen level. The authors of recent review posit that moderate fever protects against ARDS in COVID-19. The body's fever response is a hallmark of infection and inflammation. An increase in core body temperature of a few degrees (no higher than ~102°F) is generally recognized as safe (https://pubmed.ncbi.nlm.nih.gov/23199670/) and improves survival from and resolution of many infections. For example, e... inflammation covid-19
Read moreThe human immune system loses function with age in a process known as immunosenescence. Previous research has reported on the ability of a number of drugs to impact the aging process; however, these studies have not measured the ability to reverse epigenetic aging. Research from epigenetics expert Steve Horvath is the first to demonstrate the reversal of epigenetic aging and immunosenescence of the thymus with drug therapy. The thymus is an immune organ necessary for the development of T cell populations. After the age of approximately 63, a process called thymic involution severely impairs T ... epigenetics aging thymus thymic involution metformin
Read moreCurrent dietary guidelines for people living in the United States recommend limiting calories from sugar intake to less than 10 percent of total daily calories. Despite these recommendations, evidence indicates that some people living in the United States consume as much as 23 percent of their daily calories in the form of added sugars (https://www.mdpi.com/2072-6643/12/4/985). Findings from a recent study suggest that high dietary sugar intake increases a person's risk for cancer. Cancer is the second leading cause of death in the United States. Unlike normal cells, cancer cells preferential... cancer sugar
Read moreCurrently selected for this coming member's digest (/crowdsponsor) by team member Melisa B. SARS-CoV-2, the virus that causes COVID-19, stimulates the innate immune system, causing systemic inflammation that damages the lungs. Evidence suggests that those with the most severe cases of COVID are made sicker not by increased viral replication, but by unregulated inflammation. New evidence suggests that high dose intravenous vitamin C decreases inflammation, symptom severity, and death due to COVID-19. Vitamin C is essential for proper immune regulation. White blood cells produce harmful chemical... vitamin c covid-19
Read moreHow well (and how quickly) we age depends on a confluence of genetic, environmental, and lifestyle factors. Some lifestyle behaviors, such as alcohol consumption and cigarette smoking, elicit harmful effects on multiple body systems that can accumulate over time to modulate aging. A new study demonstrates that alcohol consumption and cigarette smoking accelerate brain aging, in particular. Research indicates that smoking cigarettes alters multiple structural aspects of the brain. For example, smokers tend to have less gray matter density and volume in the frontal, occipital, and temporal lobe... brain aging alcohol tobacco dairy intelligence
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