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    <a data-turbo="false" href="/episodes/qa-39-dr-rhonda-patrick">
      <h3 class="bold">
        [Podcast] Q&amp;A #39 with Dr. Rhonda Patrick (9/03/2022)
      </h3>
</a>    <p>
      Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&amp;amp;A session.
...
          <span class="search-tag">rhonda</span>
          <span class="search-tag">exercise</span>
          <span class="search-tag">gut</span>
          <span class="search-tag">aging</span>
          <span class="search-tag">omega-3</span>
          <span class="search-tag">inflammation</span>
          <span class="search-tag">fasting</span>
          <span class="search-tag">cold stress</span>
          <span class="search-tag">senescence</span>
          <span class="search-tag">supplements</span>
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    <a data-turbo="false" href="/topics/sulforaphane">
      <h3 class="bold">
        [Topic] Sulforaphane
      </h3>
</a>    <p>
      ... processing techniques), the myrosinase hydrolyzes neighboring glucosinolates to yield glucose, hydrogen sulfate, and several unstable aglycones (non-<span class="text-highlight">sugar</span> molecules). 
These aglycones can spontaneously rearrange to form various bioactive compounds, including isothiocyanates, nitriles, and others.[re...
          <span class="search-tag">sulforaphane</span>
          <span class="search-tag">cancer</span>
          <span class="search-tag">behavior</span>
          <span class="search-tag">supplements</span>
          <span class="search-tag">brain</span>
          <span class="search-tag">breast cancer</span>
          <span class="search-tag">inflammation</span>
          <span class="search-tag">autism</span>
          <span class="search-tag">antioxidant</span>
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    <a data-turbo="false" href="/topics/small-vessel-disease">
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        [Topic] Small vessel disease
      </h3>
</a>    <p>
      ...reduced markers of oxidative stress and reduced dizziness and disability.[ref doi=&#39;​​10.2174/1566524018666180720165055&#39;]
Diets that minimize salt and <span class="text-highlight">sugar</span> intake have a demonstrated relationship with lower small vessel disease risk. Among individuals who had experienced a stroke, a dietary history t...
          <span class="search-tag">small vessel disease</span>
          <span class="search-tag">brain</span>
          <span class="search-tag">alzheimer&#39;s</span>
          <span class="search-tag">vitamin d</span>
          <span class="search-tag">omega-3</span>
          <span class="search-tag">parkinson&#39;s</span>
          <span class="search-tag">inflammation</span>
          <span class="search-tag">cardiovascular</span>
          <span class="search-tag">blood-brain barrier</span>
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    <a data-turbo="false" href="/topics/blood-brain-barrier">
      <h3 class="bold">
        [Topic] Blood-brain barrier
      </h3>
</a>    <p>
      ...their responsiveness to insulin to protect themselves from the oxidative stress caused by excess caloric intake. As insulin resistance worsens, blood <span class="text-highlight">sugar</span> levels become chronically elevated, leading to long-term remodeling of the blood-brain barrier. Changes include the thickening of membranes, a re...
          <span class="search-tag">omega-3</span>
          <span class="search-tag">immune system</span>
          <span class="search-tag">blood-brain barrier</span>
          <span class="search-tag">brain</span>
          <span class="search-tag">alzheimer&#39;s</span>
          <span class="search-tag">gut</span>
          <span class="search-tag">obesity</span>
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      <h3 class="bold">
        [Topic] Toll-like receptors
      </h3>
</a>    <p>
      ...scle directly interferes with insulin sensing pathways.[ref doi=&#39;10.1371/journal.pone.0063983&#39;] Loss of insulin sensitivity in muscle increases blood <span class="text-highlight">sugar</span> levels, contributing to type 2 diabetes and cardiovascular disease development.
The endothelial cells that line blood vessels are also sensitive ...
          <span class="search-tag">toll-like receptors</span>
          <span class="search-tag">gut</span>
          <span class="search-tag">aging</span>
          <span class="search-tag">microbiome</span>
          <span class="search-tag">inflammation</span>
          <span class="search-tag">immune system</span>
          <span class="search-tag">intestinal permeability</span>
          <span class="search-tag">omega-3</span>
          <span class="search-tag">endotoxemia</span>
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    <a data-turbo="false" href="/topics/beta-hydroxybutyrate">
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        [Topic] Beta-hydroxybutyrate
      </h3>
</a>    <p>
      ...rugs used to treat type 2 diabetes that reduce the reuptake of glucose in the kidney, increasing the amount of glucose in the urine, decreasing blood <span class="text-highlight">sugar</span> levels, and increasing the production of ketones by the liver.[ref doi=&#39;10.1111/dom.13488&#39;] 
Effects on cellular senescence
Research in rodents a...
          <span class="search-tag">butyrate</span>
          <span class="search-tag">exercise</span>
          <span class="search-tag">fasting</span>
          <span class="search-tag">aging</span>
          <span class="search-tag">ketosis</span>
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      <h3 class="bold">
        [Topic] Brain-derived neurotrophic factor (BDNF)
      </h3>
</a>    <p>
      ...he links between BDNF and depression, anxiety, and anorexia; BDNF&#39;s effects on appetite and possibly aggression; the role of BDNF in regulating blood <span class="text-highlight">sugar</span> levels; and the effects of dietary supplements on BDNF levels. Some experimental challenges and open questions in BDNF research are also covered....
          <span class="search-tag">exercise</span>
          <span class="search-tag">omega-3</span>
          <span class="search-tag">meditation</span>
          <span class="search-tag">brain</span>
          <span class="search-tag">alzheimer&#39;s</span>
          <span class="search-tag">parkinson&#39;s</span>
          <span class="search-tag">fasting</span>
          <span class="search-tag">memory</span>
          <span class="search-tag">interesting</span>
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    <a data-turbo="false" href="/topics/vitamin-c">
      <h3 class="bold">
        [Topic] Vitamin C
      </h3>
</a>    <p>
      ... possible that low vitamin C levels contribute to increased fat storage. An in vivo study in mice that were fed an obesogenic diet (high fat and high <span class="text-highlight">sugar</span>) with or without vitamin C found that vitamin C reduced body weight gain, particularly in terms of fat mass, compared to mice fed the obesogenic ...
          <span class="search-tag">cancer</span>
          <span class="search-tag">nutrition</span>
          <span class="search-tag">exercise</span>
          <span class="search-tag">interesting</span>
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    <a data-turbo="false" href="/topics/resveratrol">
      <h3 class="bold">
        [Topic] Resveratrol
      </h3>
</a>    <p>
      ...ivity in visceral adipose tissue.[ref doi=&#39;10.1016/j.cmet.2013.09.004&#39;] In a similar study in non-human primates that were fed a diet high in refined <span class="text-highlight">sugar</span> (sucrose) and fat for two years, the animals experienced a 40 percent increase in arterial stiffness and inflammation. However, when fed the same...
          <span class="search-tag">exercise</span>
          <span class="search-tag">resveratrol</span>
          <span class="search-tag">alzheimer&#39;s</span>
          <span class="search-tag">metabolism</span>
          <span class="search-tag">cardiovascular</span>
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    <a data-turbo="false" href="/episodes/satchin-panda">
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        [Podcast] Satchin Panda, Ph.D. on Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass &amp; Heart Health
      </h3>
</a>    <p>
      Dr. Satchin Panda discusses the roles that fasting, time-restricted eating, and circadian rhythms play in human health.
...
          <span class="search-tag">fasting</span>
          <span class="search-tag">obesity</span>
          <span class="search-tag">podcast</span>
          <span class="search-tag">circadian rhythm</span>
          <span class="search-tag">melatonin</span>
          <span class="search-tag">video</span>
          <span class="search-tag">fatty liver</span>
          <span class="search-tag">time-restricted eating</span>
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