Lactate boosts cognitive function in mice, according to a new study. Mice had better spatial working and long-term memory after exercising and receiving supplemental lactate. Researchers studied the effects of exercise – with or without supplemental lactate – on cognitive function in mice. The mice engaged in moderate-intensity exercise (about 55 to 60 percent of their VO2 max) five days a week for five weeks. This level of intensity is just below the "lactate threshold" – the point at which lactate builds up in the bloodstream and compromises performance. At the end of the five-week period, ... exercise brain dementia bdnf lactate
Read moreMice that regularly ate nitrite-containing frankfurters developed 75 percent more gastrointestinal tumors than those that ate regular mouse food, according to a new study. The frankfurter-eating mice also gained more weight. Researchers fed mice regular mouse chow or mouse chow combined with either nitrite-free pork, nitrite-free pork sausage, or nitrite-containing frankfurter (a type of hotdog). After the mice had been on their respective diets for eight weeks, the researchers counted the animals' gastrointestinal tumors and gut microbes. They also assessed the animals' metabolic status. ...
Read more[toc position='left'] Background [tweetbox text='"Because BHB is involved in such foundational cellular functions as gene regulation, increasing BHB concentrations may be protective against a wide range of diseases."' tweet='"Because BHB is involved in such foundational cellular functions as gene regulation, increasing BHB concentrations may be protective against a wide range of diseases." https://www.foundmyfitness.com/topics/beta-hydroxybutyrate'] Beta-hydroxybutyrate (BHB) is an endogenous (i.e., produced by the body) ketone produced via the breakdown of fats during times of carbohydrate sc... butyrate exercise fasting aging ketosis
Read moreBeta-hydroxybutyrate reduces symptoms of gout. Gout is a painful, debilitating disease that affects more than 8 million people living in the United States. The condition arises when uric acid crystals form in and around the joints, causing inflammation, pain, and impaired mobility. Evidence from a 2017 study suggests that beta-hydroxybutyrate inhibits the activity of the NLRP3 inflammasome, reducing symptoms of gout. Beta-hydroxybutyrate is a type of ketone body. It forms in the liver via the breakdown of fatty acids and can be used to produce energy in the mitochondria. Beta-hydroxybutyrate ... nutrition diet ketosis inflammation arthritis nlrp3 ketogenic diet
Read moreGlobal climate change is driving an increase in wildfire activity characterized by larger fires and longer fire seasons. Wildfire smoke, which can spread over immense geographical areas, often contains a variety of pollutants and exerts a wide range of adverse effects on human health. Evidence from a new rodent study suggests that particulate matter in wildfires drives neuroinflammation, increasing the risk for neurodegenerative diseases. Particulate matter in air pollution is a mixture of solid particles and liquid droplets. It is present in fine inhalable particles, with diameters that are ... pollution neurodegeneration
Read morePsilocybin is a bioactive psychedelic compound present in certain varieties of mushrooms, commonly referred to as "magic" mushrooms. With clinical trials finding psilocybin treatment to be effective at reducing symptoms of treatment-resistant depression (https://pubmed.ncbi.nlm.nih.gov/27210031/) and obsessive compulsive disorder (https://pubmed.ncbi.nlm.nih.gov/17196053/), increasingly more attention is being drawn to the potential mental health benefits of the compound. Findings from a recent study indicate that a single dose of psilocybin triggers a tangible and lasting proliferation of new... brain mushroom psychedelic lsd
Read more[toc position='left'] Brain-derived neurotrophic factor, or BDNF, is a growth factor relevant to aging, brain function, behavior, metabolism, energy expenditure, and satiety. BDNF serves as a cell signaling protein, plays vital roles in numerous signaling pathways associated with a variety of disorders ranging from depression, (https://www.foundmyfitness.com/topics/depression) schizophrenia, and addiction to obesity and diabetes, and may serve as a hormone. It is perhaps best known for its influence on the formation, growth, survival, and development of neurons and for its role in mediating th... exercise omega-3 meditation brain alzheimer's parkinson's fasting memory interesting
Read moreRhonda explains NAD+: importance for aging, decline with age, boosters (nicotinamide riboside, nicotinamide mononucleotide), and data in animals and humans. ... aging dna damage genetics resveratrol
Watch now[toc position='right'] Resveratrol is a natural compound found primarily in the skin of red grapes and the root of Polygonum cuspidatum (also known as Japanese knotweed). It is also present to a lesser degree in peanuts and blueberries. Resveratrol protects the plants in which it is present from fungal attack and the damaging effects of ultraviolet radiation. Originally extracted in the 1940s, resveratrol attracted little interest in terms of human health until 1992 when research suggested that it could mediate some of the cardioprotective effects of red wine.[ref doi='10.3390/molecules220202... exercise resveratrol alzheimer's metabolism cardiovascular
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