[toc position='left'] Thymic involution is the process by which the thymus shrinks with age and produces fewer T cells, impairing immunity and increasing the risk of infection in older adults. In addition, thymic involution increases the risk of cancer and autoimmunity with age. However, research has identified some of the mechanisms of thymic involution and highlighted possible strategies to improve immunity: By activating PPAR-gamma, a protein that regulates fat metabolism, caloric restriction reduced the rate of thymic involution in mice and increased the number and diversity of circulatin... thymic involution immune system thymus autoimmunity
Read more[toc position='left'] Carotenoids are orange/yellow pigments in various foods, such as carrots, pumpkins, avocados, and salmon. While carotenoids are a highly diverse group of organic pigments, with over 1,100 known carotenoids [ref doi='10.1093/database/bax004'], this overview will focus on lutein and zeaxanthin, which are of particular interest due to their notable roles in eye and brain health. Carotenoids are one of the most common classes of bioactive compounds found in plants, along with alkaloids (e.g., berberine), organosulfur compounds (e.g., sulforaphane), and polyphenols (e.g., anth... carotenoids cholesterol eyes antioxidant
Read more[toc position='left'] Sugar-sweetened beverages (SSB) include commonly consumed products such as soda, sports drinks, and energy drinks; coffee, tea, and water with added sugars; and some fruit juices, although not all nutrition experts agree on fruit juice’s inclusion as an SSB. While the consumption of SSBs has declined in recent decades, they remain a leading contributor to sugar intake among people living in the United States. While the over-consumption of sugar from any source is harmful for health, SSBs present a physiologically unique risk to health due to a converging set of factors. B... nutrition diet biomarkers triglycerides sugar question cancer obesity diabetes cholesterol testosterone insulin carbohydrates blood sugar metabolic syndrome sugar-sweetened beverages
Read moreDr. Bill Harris discusses the roles that omega-3 fatty acids play in cardiovascular and neurocognitive health. ... omega-3 brain aging heart disease biomarkers inflammation immune system pregnancy mortality polyunsaturated fat
Watch nowDr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session. ... rhonda exercise aging vitamin c omega-3 stem cells fasting magnesium vitamin e vaccine vitamin k allergies resveratrol sauna time-restricted eating blood sugar breast milk
Watch now[toc position='left'] Background Collagens are major structural proteins in numerous body tissues, including tendons, ligaments, cartilage, skin, blood vessels, muscles, gut tissue, and dentin.[ref doi='10.1101/cshperspect.a004978'] They are the most abundant proteins in the body, comprising 30 percent of the total protein mass. The human body continuously manufactures collagens to maintain tissue structural integrity. However, aging drives a progressive decrease in protein synthesis and reduced capacity to produce new collagen.[ref doi='10.1016/S0047-6374(01)00337-2'] Collagens are also highl... interesting nutrition aging metabolism autoimmunity menopause
Read more[toc position='left'] Caloric restriction is the practice of long-term reduced dietary intake, typically characterized by a 20 to 50 percent decrease in caloric intake below habitual levels, without malnutrition or deprivation of essential nutrients. It involves a consistent pattern of reducing average daily caloric intake and differs from fasting and other restrictive eating patterns in that the latter regimens primarily focus on the frequency and timing of eating rather than a pattern of permanent, long-term restriction. Caloric restriction in animals Caloric restriction delays the onset of ... diet aging
Read more[toc position='left'] Nicotinamide riboside (NR) is a precursor molecule for the biosynthesis of nicotinamide adenine dinucleotide, or NAD+, a coenzyme that participates in the production of cellular energy and repair. Two other NAD+ precursors, nicotinic acid (NA) and nicotinamide (NAM, also called niacinamide), along with nicotinamide riboside, are often collectively referred to as niacin (vitamin B3) or niacin equivalents. These precursors are not equally allocated throughout the body, exhibiting preferential distribution among the blood, brain, gut, and other organs. NAD+ can also be produ... obesity nad+ aging breast milk cardiovascular
Read more[toc position='left'] Depression is a neuropsychiatric disorder characterized by negative mood, loss of interest in doing things, and metabolic, hormonal, and immune disturbances that can degrade a person's quality of life and increase their risk of disease and death. The World Health Organization estimates that approximately 322 million people – more than 4 percent of the global population – currently live with depression,[ref doi='10.1001/jama.2017.3826'] the most common mental health disorder worldwide. Between 2005 and 2015 (the most recent years for which robust meta-analyses are availabl... inflammation probiotics circadian rhythm meditation behavior heat stress depression metabolism neurotransmitter nutrition exercise brain microbiome interesting omega-3 menopause
Read moreFOXO proteins are members of the FOX family of highly conserved transcriptional regulators. They play essential roles in human lifespan and healthy aging, influenced by environmental and genetic factors. The genetic contribution to lifespan and aging increases with time, suggesting that people who live long lives might carry so-called "protective genes." Run the longevity report to learn more about genetic polymorphisms influencing the expression of FOXO (/genetics) Background FOX proteins are named for a gene found in fruit flies that causes the insects to have forked structures on their head... aging fasting nutrition diet
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