Proteins called Yamanaka factors can reprogram differentiated (mature) cells into pluripotent stem cells. However, scientists don’t fully understand the metabolic requirements underlying this process. A new study shows that vitamin B12 supports the metabolic processes involved in cellular reprogramming. First, researchers investigated how gut bacteria influence cellular reprogramming in mice. They induced gene expression to initiate reprogramming, and then they treated the mice with antibiotics to disrupt their gut microbiota. They found that reprogramming efficiency in the colon and stomach d... gut microbiome genetic engineering micronutrients vitamin b12
Read moreDr. Martin Gibala discusses HIIT's health benefits and describes common HIIT protocols. ... exercise aging heart disease diabetes mitochondria cortisol fat muscle bone lactate exercise snacks
Watch nowCellular senescence is the condition or process of cellular deterioration that occurs with age. Senescent cells often release inflammatory proteins that can damage neighboring healthy cells. Understanding the genetic and epigenetic bases of cellular senescence is instrumental in developing interventions to slow aging. A recent report identifies a gene therapy strategy to slow aging in mice. Gene therapy is a technique in which altered (mutated) genes are corrected as a means to prevent or treat disease. One type of gene therapy involves inactivating a mutated gene that is functioning improper... aging genetic engineering senescence
Read moreThe epigenetic clocks of transplanted cells and their descendants synchronize with the donor, offering promise for human rejuvenation. ... epigenetics aging tissue repair genetics
Watch nowTim Ferriss and Dr. Rhonda Patrick discuss acute versus chronic inflammation and how supplemental antioxidants can reduce exercise benefits. ... inflammation exercise fasting stress mitochondria antioxidant
Watch nowDr. Jed Fahey describes the current state of the science of understanding how sulforaphane influences longevity. ... sulforaphane aging nrf2
Watch nowIn this clip, Dr. David Sinclair describes the links between NAD+, sirtuins, and resveratrol in the aging process. ... aging resveratrol
Watch nowDr. Rhonda Patrick describes some of the different types of fasting and identifies the advantages associated with each. ... fasting dna damage autophagy time-restricted eating
Watch nowDr. Valter Longo describes how a fasting-mimicking diet can be used for fat loss while preserving lean muscle mass. ... fasting exercise obesity performance visceral fat
Watch nowDr. Guido Kroemer describes the current state of knowledge about the minimum amount of time required for fasting-induced autophagy in humans. ... autophagy aging metabolism fasting
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