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    <a data-turbo="false" href="/episodes/what-creatine-can-and-cannot-do-during-sleep-loss">
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        [Podcast] What Creatine Can and Cannot Do During Sleep Loss
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      Dr. Rhonda Patrick explains creatine loading and maintenance for muscle and explores cognition and brain energy during severe sleep loss.
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          <span class="search-tag">exercise</span>
          <span class="search-tag">brain</span>
          <span class="search-tag">aging</span>
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          <span class="search-tag">creatine</span>
          <span class="search-tag">cognition</span>
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        [Podcast] How Magnesium Supports DNA Repair
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      Dr. Rhonda Patrick explains how magnesium supports energy metabolism and DNA repair, and compares food sources with organic and oxide supplements.
...
          <span class="search-tag">exercise</span>
          <span class="search-tag">cancer</span>
          <span class="search-tag">dna damage</span>
          <span class="search-tag">magnesium</span>
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        [Podcast] How Sauna Use May Protect the Aging Brain
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      Dr. Rhonda Patrick reviews observational evidence linking frequent sauna use with lower dementia and Alzheimer&#39;s disease incidence.
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          <span class="search-tag">sauna</span>
          <span class="search-tag">alzheimer&#39;s</span>
          <span class="search-tag">inflammation</span>
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        [Podcast] The Optimal Creatine Protocol for Strength, Brain, and Longevity | Darren Candow, PhD
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      Dr. Darren Candow and Dr. Rhonda Patrick discuss the science of creatine for muscle performance and brain health.
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          <span class="search-tag">supplements</span>
          <span class="search-tag">brain</span>
          <span class="search-tag">aging</span>
          <span class="search-tag">muscle</span>
          <span class="search-tag">strength</span>
          <span class="search-tag">creatine</span>
          <span class="search-tag">cognition</span>
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        [Story] Mitochondrial control of inflammation.
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      Mitochondria are often described as cellular powerhouses. But mitochondria also play key roles in modulating inflammation. This 2022 review details the molecular mechanisms underlying mitochondrial regulation of inflammatory responses and the pathways that keep those responses in check.
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          <span class="search-tag">inflammation</span>
          <span class="search-tag">mitochondria</span>
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        [Story] Clearing out senescent cells can extend healthspan by 25% in mice. Great summary of current state of research on senescence!
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</a>    <p>
      Cellular senescence is so important when we discuss aging and cancer because as our cells accumulate damage, which naturally happens as we age there are only so many outcomes that we can expect. The first possibility is that the cells can die. The next is that they can become senescent where they stop dividing but stay alive all-the-while secreting molecules that influence surrounding tissue… or the worst of all possible outcomes, the cells can really go off the rails and become malignant.
Accumulating senescent cells is inevitable but there are varying strategies of how to tackle senescence a...
          <span class="search-tag">cancer</span>
          <span class="search-tag">senescence</span>
          <span class="search-tag">aging</span>
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        [Story] Plant chemicals can slow biological aging: willow bark increased the lifespan of yeast by 475%.
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      Plants produce natural compounds to ward off insects. At low doses, these chemicals can trigger cellular responses in the body that exceed what is actually needed to compensate for the otherwise damaging insult (called hormesis) and can slow biological aging.
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          <span class="search-tag">mortality</span>
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        [Story] Childhood adversity is associated with telomere shortening, which is a marker for accelerated aging.
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      FTA:
&amp;gt; An association between biological changes on the cellular level and both childhood adversity and psychiatric disorders has been identified by researchers. These changes in the form of telomere shortening and alterations of mitochondrial DNA (mtDNA), are important in the aging process.
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          <span class="search-tag">brain</span>
          <span class="search-tag">aging</span>
          <span class="search-tag">telomeres</span>
          <span class="search-tag">mitochondria</span>
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