[toc position='left'] Introduction Light does much more than help us see. It tells the brain what time it is. That signal coordinates sleep and wakefulness, hormone release, metabolism, mood, and hundreds of other processes that follow a roughly 24-hour rhythm. Its effects depend not simply on how much light reaches the eye, but when it arrives. Bright light in the morning and throughout the day strengthens the body's daytime signal. Dim evenings and dark nights allow the biological night to unfold. Modern life often reverses that pattern, giving us biologically dim days and unusually bright n... metabolism sleep depression mental health melatonin eyes circadian rhythm
Read moreDr. Michael Grandner and Dr. Rhonda Patrick explore treatments for insomnia, detecting hidden sleep apnea, and science-backed strategies for better sleep. ... sleep alcohol melatonin caffeine cbd performance circadian rhythm magnesium supplements L-Theanine
Watch now[toc position='left'] Creatine (https://www.foundmyfitness.com/topics/creatine) is a naturally occurring compound that is critical in storing and releasing cellular energy. It also participates in many biological processes driving pregnancy outcomes, maintaining bone mineral density and muscle mass in older adults, improving neurological function, and aiding the immune system to fight cancer. Creatine is best known for its widespread use as a dietary supplement to enhance physical performance. Creatine, phosphocreatine, creatine transporters, and creatine kinase enzymes are expressed in the en... cardiovascular heart disease
Read moreDr. Rhonda Patrick compares sauna protocols, exercise-plus-heat, heat-shock proteins, baths, mood hypotheses, and access limits. ... heat stress exercise depression sauna cardiovascular
Watch nowChronic inflammation plays a key role in the development of many chronic diseases, including cancer, cardiovascular disease, and diabetes. When it comes to m... ... aliquot cancer diabetes inflammation cardiovascular
Listen now[toc position='left'] Creatine is a naturally occurring compound that is critical in storing and releasing cellular energy. It also participates in many biological processes driving pregnancy outcomes, maintaining bone mineral density and muscle mass in older adults, improving neurological function, and aiding the immune system to fight cancer. Creatine is best known for its widespread use as a dietary supplement to enhance physical performance. Creatine uptake, synthesis, storage, and supplementation Creatine uptake Creatine can be supplied exogenously (from dietary or supplemental sources) ... metabolism neurodegeneration nutrition brain aging depression pregnancy
Read more[toc position='left'] > Epigenetic clocks are a subset of the broader subject of biological aging clocks, which you can read a full write-up on here (/topics/biological-age-clocks). Epigenetic clocks are predictors of biological age based on alterations in an individual's DNA methylation profile. Methylations – biochemical processes that modify the activity of a DNA segment without changing its sequence – occur naturally and regulate gene expression to control normal growth and development. With age, the methylation state of various genes may change. These changes are quantifiable and gauge... aging interesting epigenetics dna damage
Read more[toc position='left'] Hyperthermia, a state of elevated core body temperature, stresses the body, activating molecular mechanisms that mitigate protein damage and aggregation and promote endogenous antioxidant, repair, and degradation processes. Whole-body hyperthermia is a therapeutic strategy used to treat various medical conditions, including cancer, fibromyalgia, and others.[ref doi='10.1093/annonc/mdf280'][ref doi='10.2147/CIA.S74949'][ref doi='10.3205/000235'] Emerging evidence suggests that whole-body hyperthermia might be useful in treating depression.[ref doi='10.1001/jamapsychiatry.2... sauna cancer depression
Read moreDr. Patrick discusses some of the compelling evidence that suggests exercise is a tool for preventing or managing the symptoms of depression. ... depression exercise mental health
Watch nowDr. Satchin Panda discusses the practical aspects of implementing fasting, time-restricted eating, shift work strategies, and more. ... fasting cancer obesity metabolism diabetes circadian rhythm melatonin time-restricted eating
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