IL-6 may drive inflammation in neuropsychiatric disorders. Neuropsychiatric disorders are the leading cause of disability among people living in the United States, accounting for nearly 20 percent of all years of life lost to disability and premature death (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436627/). Evidence suggests that brain inflammation is a key player in neuropsychiatric disorders, the effects of which may be bidirectional. (https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/nyas.13712) A recent study identified potential links between inflammation and structural alter... brain inflammation mental health genetics il-6
Read moreDr. Patrick's keynote: compromised intestinal barrier affects human health—cardiometabolic function, neurological health, behavior, and more. ... intestinal permeability alzheimer's gut heart disease inflammation depression blood-brain barrier lipopolysaccharide
Watch now[toc position='left'] Aging refers to the collective physiological, functional, and mental changes that accrue in a biological organism over time. The hallmarks of aging are observable biological patterns of dysfunction that occur with aging. Integral to the aging process is inflammaging, the chronic, low-grade inflammation that occurs with aging.[ref doi='10.1111/j.1749-6632.2000.tb06651.x'] The mechanisms that drive inflammaging and the pathological conditions that arise because of it are bidirectional and involve multiple physiological processes and pathways, many of which directly or indir... mitochondria aging omega-3 stem cells aerobic senescence
Read more[toc position='left'] Carotenoids are orange/yellow pigments in various foods, such as carrots, pumpkins, avocados, and salmon. While carotenoids are a highly diverse group of organic pigments, with over 1,100 known carotenoids [ref doi='10.1093/database/bax004'], this overview will focus on lutein and zeaxanthin, which are of particular interest due to their notable roles in eye and brain health. Carotenoids are one of the most common classes of bioactive compounds found in plants, along with alkaloids (e.g., berberine), organosulfur compounds (e.g., sulforaphane), and polyphenols (e.g., anth... carotenoids cholesterol eyes antioxidant
Read moreHeart disease is the number one cause of death in the United States, owing to a constellation of risk factors including a sedentary lifestyle, disrupted sleep patterns, stress, and poor diet. The average American adult consumes 29 grams of saturated fat per day (https://www.ars.usda.gov/northeast-area/beltsville-md-bhnrc/beltsville-human-nutrition-research-center/food-surveys-research-group/docs/wweia-data-tables/) (the amount in about four tablespoons of butter, four slices of pepperoni pizza, or 1.5 cups of ice cream), possibly contributing to heart disease risk through interactions with the... microbiome heart disease fat
Read moreThe gut microbiota is composed of the community of bacteria, archaea, fungi, and viruses that live in the human intestine. Dietary components influence the composition and activity of the microbiota. For example, foods high in dietary fiber, such as whole grains and beans, and fermented foods, such as yogurt and sauerkraut, support an abundant and diverse gut microbiota, which is associated with lower disease risk (https://www.nature.com/articles/nrg3182). Authors of a report released this week investigated the effects of high-fiber and fermented foods on the gut microbiota and immune system. ... gut microbiome probiotics il-6
Read moreDepression is characterized by mood alterations, such as increased sadness and irritability, and physiological changes, such as decreased sleep, appetite, and sexual desire. Previous research has reported a relationship between increased muscle strength and lower depression risk in older adults (https://pubmed.ncbi.nlm.nih.gov/33069120/). Findings of a recent study detail the relationship between muscle strength and depression risk in young adults. Cytokines are proteins that participate in cell-signaling. Pro-inflammatory cytokines are increased in depression and contribute to the dysfunction... exercise brain depression muscle il-6
Read moreExposure to air pollutants is associated with an increased risk of developing many health disorders, including heart disease, stroke, chronic obstructive pulmonary disease, lung cancer, and acute respiratory infections. Some evidence suggests that exposure to air pollution can impair neurological development in children (https://www.who.int/airpollution/ambient/health-impacts/en/). A 2014 study showed that reducing exposure to polycyclic aromatic hydrocarbons (PAHs) was associated with improved cognitive development and increased BDNF levels in children. Polycyclic aromatic hydrocarbons are p... brain development pollution bdnf
Read more[toc position='left'] Salmon roe – sometimes referred to as "salmon caviar" – is the internal egg mass found in female salmon. It is served in a variety of dishes, including sushi and pasta, or as a garnish or condiment to seafood or eggs. Salmon roe is rich in protein, vitamins, astaxanthin, and the omega-3 fatty acids eicosapentaenoic acid, or EPA, and docosahexaenoic acid, or DHA. Omega-3 fatty acids are long-chain polyunsaturated fatty acids. They are considered essential fatty acids because the human body cannot make them. Alpha-linolenic acid, or ALA, an omega-3 fatty acid that serves a... brain aging omega-3 diet mental health dementia alzheimer's
Read moreDr. Rhonda Patrick makes her seventh appearance on the Joe Rogan Experience. ... rhonda nutrition brain diet aging ketosis heart disease cholesterol vaccine testosterone autism
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