The ovary is among the first organs to show age-related declines in women. Researchers combined large human datasets with mouse experiments to test whether physical activity might alter that trajectory. The researchers first examined the relationship between self-reported physical activity and menopause in two large human datasets, then had female mice exercise regularly on a treadmill for one month while controls spent the same sessions on it without running. Afterward, they counted primordial follicles, the dormant follicles that contain immature eggs, and measured a hormone marker of ovaria... exercise hormones menopause
Read moreWeight loss can look successful on the scale while concealing whether the body lost fat or muscle. Researchers tested whether raising ketone levels during treatment with semaglutide, the weight-loss drug sold under brand names such as Ozempic and Wegovy, could protect skeletal muscle without interfering with fat loss. Male mice with diet-induced obesity and poor blood sugar control entered a three-week rapid-weight-loss experiment as they switched from a high-fat diet to regular food under calorie-deficit conditions. They were randomly assigned to inactive saline control injections, semaglutid... Exogenous ketones fat GLP-1 ketosis muscle weight loss
Read moreBeta-glucan versus psyllium for lowering LDL, PFAS reduction, creatine and caffeine, urolithin A, exogenous ketones, IVF, Botox, and sauna. ... rhonda pollution fiber sauna caffeine supplements urolithin a creatine reproductive health Exogenous ketones cholesterol Ubiquinol PFAS
Watch nowDr. Rhonda Patrick discusses protein needs, choline in pregnancy, urolithin A, melatonin's benefits and risks, and creatine's effects on liver health. ... rhonda pregnancy omega-3 melatonin fatty liver urolithin a creatine choline menopause
Watch nowMaintaining oral health may play a more important role in brain aging than previously recognized. A new study from Korea followed middle-aged and older adults to see if oral health could help predict future memory problems. The study tracked more than 6,700 adults aged 45 and older without a diagnosis of mild cognitive impairment (MCI) or dementia, who answered questions about their oral health at the start of the study. Over the next four years, they took part in regular interviews that recorded any new physician diagnoses of MCI or dementia. The key measures were: Overall oral health, ass... dementia
Read moreNeural tube defects (e.g., spina bifida, hydranencephaly) are a group of birth defects caused by incomplete development of the outer layers of the brain or spinal cord. Prenatal folate supplementation prevents an estimated 70 percent of neural tube defects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279093/), but additional therapies are needed. A recent report describes the relationship between maternal diabetes and abnormal cell aging in the fetal nervous system in mice. Previous research has demonstrated a relationship between maternal diabetes and the incidence of neural tube defects (h... brain aging diabetes pregnancy
Read moreCOVID-19 is caused by infection from SARS-CoV-2, a type of coronavirus. Following SARS-CoV-2 infection, the immune system produces antibodies specific for the SARS-CoV-2 spike protein that prevent reinfection. However, research from early in the COVID-19 pandemic reported a rapid loss of these antibodies a few months after infection. Findings of more recent research suggest SARS-CoV-2 immunity may last longer than previously thought. B cells are white blood cells that originate in the bone marrow. During an infection, mature B cells enter the bloodstream as plasma cells, where they are activat... covid-19
Read moreThe chronic inflammation that accompanies ulcerative colitis, a type of inflammatory bowel disease, increases the risk of developing colon cancer. New research in mice suggests a component of cannabis may prevent the development of colitis-associated colon cancer. Cannabis, also known as marijuana, contains a family of chemicals called cannabinoids, including the psychoactive compound, tetrahydrocannabinol (THC). THC binds to cannabinoid receptors (CB), present throughout the body, altering appetite, pain, mood, and memory. CB1 receptors are more common in the brain, while CB2 receptors are ma... cancer cannabinoid
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