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    <a data-turbo="false" href="/episodes/how-urolithin-a-supports-mitochondrial-health">
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        [Podcast] How Urolithin A Supports Mitochondrial Health
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      Dr. Rhonda Patrick explains urolithin A, mitophagy, muscle function, dosing, food timing, and continuous use.
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        [Podcast] What Alpha-Lipoic Acid Does in Metabolism
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      Dr. Rhonda Patrick explains alpha-lipoic acid as a mitochondrial cofactor and reviews its effects on lipids, glucose, and oxidative stress.
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        [Topic] Magnesium
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Introduction
Magnesium is an essential dietary mineral. It plays critical roles in myriad physiological processes, serving as a cofactor to more than 300 enzymes in the human body and maintaining the integrity of cellular structures and DNA. Magnesium deficiency is widespread, affecting more than half of people in the U.S. and increasing the risk of many chronic conditions, including cancer, metabolic disorders, and neurodegenerative diseases.  
At a glance, magnesium participates in: 
Enzymatic reactions, serving as a cofactor for more than 300 enzymes involved in variou...
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        [Podcast] The effect of vigorous exercise on fat oxidation and mitochondria | Dr. Martin Gibala
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      In this clip, Dr. Martin Gibala outlines the relationship between exercise types, mitochondrial growth, and their combined effect on fat metabolism.
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        [Topic] Sulforaphane
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Sulforaphane is a bioactive compound derived from certain cruciferous vegetables, particularly broccoli (and its sprouts) and red kale. Robust evidence from epidemiological, clinical, rodent, and in vitro studies has demonstrated that sulforaphane exhibits antioxidant and anti-inflammatory properties and may be beneficial against a wide range of chronic and acute diseases, including autism, cancer, metabolic dysfunction, and many others and may ameliorate some of the harmful effects associated with exposure to air pollution.  
Sulforaphane exerts its therapeutic effects t...
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        [Topic] Metformin
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Metformin is a drug commonly used to treat type 2 diabetes. It is the fourth most widely prescribed medication in the United States, with more than 80 million prescriptions for the drug written yearly. Metformin is in a class of drugs called biguanides, which impede liver gluconeogenesis (glucose production in the liver), thereby decreasing glucose uptake in the gut and increasing overall glucose utilization by improving insulin sensitivity in skeletal muscle and fat tissue. Multiple studies demonstrate that metformin reduces fasting blood glucose levels by as much as 3.9...
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        [Podcast] Why we lose NAD+ in aging [DNA repair &amp; inflammation] | David Sinclair
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      In this clip, Dr. David Sinclair explains why NAD+ levels decrease with age. 
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        [Podcast] Dr. Eric Verdin on Ketogenic Diet, Longevity, Beta-Hydroxybutyrate, HDAC Inhibitors, &amp; NAD+
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      Dr. Eric M. Verdin discusses the roles of the ketogenic diet, beta-hydroxybutyrate, HDAC inhibitors, NAD+, and more in the context of aging.
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        [Podcast] Ruth Patterson, PhD, on Time-Restricted Eating in Humans &amp; Breast Cancer Prevention
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      Dr. Ruth Patterson discusses the role of fasting in the prevention and survivorship of breast cancer. 
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        [Podcast] Dominic D&#39;Agostino, Ph.D. on Modified Atkins Diet, Ketosis, Supplemental Ketones and More
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      Dr. Dominic D&#39;Agostino discusses the health benefits associated with a modified Atkins diet, ketosis, and supplemental ketones.
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