Why we lose NAD+ in aging [DNA repair & inflammation] | David Sinclair

Parent Episode: Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

As we age, immune system activation and increased levels of DNA damage utilize much of the body's NAD+. The body also produces less NAD+ over time, creating a vicious cycle of increased need and decreased production. This can lead to genomic instability – a wide range of alterations that occur in our DNA and irreversibly change the information carried in our genome. Sirtuins respond quickly to DNA damage within a cell, directing gene expression to promote DNA repair. This serves as a distraction to sirtuins, however, ultimately drawing them away from their primary role. In the end, the cell experiences a sort of "identity crisis," unable to perform its original job, leading to aging. In this clip, Dr. David Sinclair explains why NAD+ levels decrease with age.

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