Physical activity guidelines recommend 150–300 minutes of moderate or 75–150 minutes of vigorous activity per week, but it remains unclear whether short bursts spread throughout the day are linked to long-term benefits similar to longer bouts of exercise. A new study examined how these different activity patterns were associated with the risk of death and cardiovascular disease. The study included 96,054 middle-aged and older adults from the UK Biobank, with an average age of 62. Researchers used seven days of data from wrist-worn activity trackers to estimate how much moderate-to-vigorous ph... cardiovascular exercise exercise snacks mortality
Read moreParenthood reshapes daily life in ways that could influence brain health and aging, yet its long-term effects are largely unknown. A study examined whether the number of children people had was linked to differences in cognitive performance and brain age in both women and men. Researchers included 303,196 UK Biobank participants of European ancestry who had no diagnosed brain or nervous-system disorders. The sample comprised 160,077 women, with an average age of 56.7 years, and 143,119 men, with an average age of 57.5 years. Participants were grouped according to whether they had no children, ... aging brain cognition pregnancy
Read moreTestosterone therapy is increasingly prescribed beyond men with confirmed testosterone deficiency, but its long-term cardiovascular safety in that setting is not well established. A new study compared long-term cardiovascular outcomes in men starting testosterone therapy with and without documented evidence of symptomatic testosterone deficiency. Researchers used electronic health records from 358,957 men aged 30 to 75 who had started testosterone therapy. Available diagnoses and testosterone test results were used as evidence of hypogonadism, the clinical condition of testosterone deficiency... cardiovascular heart disease mortality stroke testosterone
Read morePeople with type 2 diabetes often experience sharp rises in blood sugar and blood fats after eating, changes that increase the risk of heart disease over time. Researchers investigated whether drinking a ketone supplement before a meal could improve these metabolic swings. The research consisted of two carefully controlled crossover studies in adult patients with type 2 diabetes who were treated with lifestyle changes or metformin. In the first study, 14 participants drank one of three beverages 30 minutes before a standardized meal: a ketone monoester, a ketone salt, or a placebo. In the sec... diabetes Exogenous ketones
Read moreIn this episode, we’re taking a deep dive into alcohol. We’ll explore the science, misconceptions, controversies, and health effects of this widely used drug. ... alcohol exercise brain alzheimer's cancer aging microbiome sleep heart disease
Watch nowTraditionally, governments and public health authorities have placed a high emphasis on recommending physical activity as a means of combating weight gain and obesity. Yet, randomized controlled trials have found exercise alone to have a relatively modest effect on body weight, yielding weight loss averages in the order of 4 (https://pubmed.ncbi.nlm.nih.gov/21787904/) to 11 (https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/215659) pounds (2 to 5 kilograms) in people with overweight and obesity. Some researchers have posited that metabolic adaptation (https://pubmed.ncbi.nlm.ni... exercise obesity metabolism
Read moreAging causes brain changes that impair cognitive function, even in people who do not have Alzheimer’s disease or dementia. However, lifestyle factors like diet and exercise have significant influence over the rate of cognitive decline. Previous research has shown that exercise improves brain health and cognitive function during aging. A new report details the role of the muscle hormone irisin in the neuroprotective effects of exercise Irisin, a type of myokine, is a hormone secreted from muscle in response to exercise. Previous research has shown that irisin may mediate some of the beneficial ... exercise brain alzheimer's aging hormones neurodegeneration
Read moreCOVID-19 Q&A Part 2: Rhonda Patrick, Ph.D. answers subscriber questions in a multi-part series. ... covid-19 vitamin d nutrition exercise microbiome sleep vitamin c omega-3 inflammation immune system virus micronutrients vitamin e vaccine genetics testosterone estrogen zinc fiber autoimmunity
Watch nowThe dietary supplement market comprises a $40 billion industry in the United States. The Dietary Supplement Health and Education Act – legislation enacted in 1994 stipulating that the FDA regulate dietary supplements as food, so they are not subject to premarket approval or the same effectiveness and safety testing required for drugs – left the industry largely unregulated. A recent editorial reports that many dietary supplements may be contaminated with heavy metals or microbes or may contain synthetic drugs or ingredients not listed on their labeling. Dietary supplements comprise a wide ran... vitamin a supplements
Read moreDr. Valter Longo discusses fasting as a means to treat or prevent age-related diseases such as cancer, Alzheimer’s disease, and others. ... fasting cancer obesity aging heart disease diabetes insulin resistance inflammation stem cells immune system tissue repair autophagy apoptosis insulin autoimmunity
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